{
  "abstract": "Objectives: To assess the utilization of ceftazidime-avibactam at Thong Nhat Hospital, a national hospital in Vietnam. Methods: A descriptive cross-sectional study was conducted using retrospective data from medical records of inpatients aged ≥ 18 years who received ceftazidime-avibactam for at least 2 days between January 2023 and March 2025 at Thong Nhat Hospital, Vietnam. The appropriateness of ceftazidime-avibactam use was evaluated based on Thong Nhat Hospital’s antibiotic use guideline. The backward conditional method was used to identify factors associated with patient treatment outcomes. Results: A total of 101 patients were included, with a median age of 78 years (68−86). Respiratory and bloodstream infections were the most common types, accounting for 84.15% and 44.55% of cases, respectively. Gram-negative bacteria comprised 76.05% of isolates, with Klebsiella pneumoniae (26.47%), Klebsiella aerogenes (18.50%) and Pseudomonas aeruginosa (10.50%) being the most frequent. The susceptibility rate to ceftazidime-avibactam was 71.43% for Klebsiella pneumoniae, 95.65% for Klebsiella aerogenes and 42.86% for Pseudomonas aeruginosa. OXA-48 was the most detected carbapenemase gene (37.84%). The overall appropriateness rate of ceftazidime-avibactam use was 70.30%. The treatment success rate was 39.60%. Treatment in the intensive care unit was associated with decreased treatment success, while comorbid heart failure showed a potential association. Conclusions: The treatment success rate with ceftazidime-avibactam in this study was relatively low. Continuous surveillance of microbiological profiles and antibiotic resistance, particularly to ceftazidime-avibactam, is essential to better guide the management of drug-resistant Gram-negative infections at the hospital.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Clinical Pharmacy, School of Pharmacy, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam",
    "Department of Pharmacy, Thong Nhat Hospital, Ho Chi Minh City, Vietnam"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
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        0
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      "name": "Khue Dang Minh Van"
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    {
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        1
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      "name": "Han Ngoc Bao Pham"
    },
    {
      "name": "An Thi Thanh Nguyen"
    },
    {
      "name": "Nhi Truc Y. Nguyen"
    },
    {
      "name": "Cam Thi Le Pham"
    },
    {
      "name": "Nhan Thi Thanh Dang"
    },
    {
      "name": "Quynh Thi Huong Bui"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0a9sm283bch3r.bib",
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  "doi": "10.1371/journal.pone.0359631",
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    "1932-6203"
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  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
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  "native_subjects": [
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      "openalex",
      "2402|Antibiotic Use and Resistance"
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      "/Biology and life sciences/Anatomy/Renal system"
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      "/Medicine and health sciences/Cardiology/Heart failure"
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      "/Medicine and health sciences/Hematology/Bloodstream infections"
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      "/Medicine and health sciences/Pathology and laboratory medicine/Pathogens/Microbial pathogens/Bacterial pathogens/Pseudomonas aeruginosa"
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      "/Medicine and health sciences/Pharmacology/Antimicrobial resistance"
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      "/Medicine and health sciences/Pharmacology/Drugs/Antimicrobials/Antibiotics"
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      "plos",
      "/Medicine and health sciences/Urology/Genitourinary infections/Urinary tract infections"
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  "pdf_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0359631&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-13",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/0a9sm283bch3r.ris",
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    {
      "first_seen": "2026-10-30T12:17:23Z",
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  "subjects": [
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  "title": "Investigation on the use of ceftazidime-avibactam at a national hospital in Vietnam",
  "title_text": "Investigation on the use of ceftazidime-avibactam at a national hospital in Vietnam",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:30Z",
  "url": "https://research.draconitic.com/paper/0a9sm283bch3r",
  "venue": "PLOS One",
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