{
  "abstract": "Chirality, a fundamental characteristic of nature, plays a decisive role in molecular recognition, catalysis, and cellular organization. Translating this asymmetry into synthetic systems has the potential to unlock new functionalities at the interface of nanoscience and biology. Here, we report the first synthesis of high aspect ratio chiral gold nanofibers, a class of one-dimensional chiral plasmonic materials, fabricated via a seedless, soft-templated, ligandassisted growth method. Using D- and L-cysteine as chiral inducers, we direct the anisotropic reduction of gold ions to produce left- and right-handed nanofibers with tunable surface topologies. The resulting chiral gold nanofibers exhibit pronounced, mirror-symmetric circular dichroism signals and characteristic plasmonic resonances, confirming their intrinsic structural chirality. 4D scanning transmission electron microscopy analysis demonstrates that the atoms arrange in a chiral fashion, governing the final chirality of the gold nanofibers. Beyond their optical properties, these gold nanofibers provide topographical cues that promote directed neuron cell alignment when integrated into paper-based chips, offering a simple platform to model neuronal organization. Altogether, this effort establishes a scalable route to chiral gold architectures and demonstrates their capacity to couple plasmonic chirality with biological function, opening a new pathway for nanomaterials-based neuroregeneration.",
  "abstract_shown": true,
  "affiliations": [
    "Interdisciplinary Nanoscience Center (iNANO",
    "Aarhus University",
    "University of Chinese Academy of Sciences",
    "Center for Sustainable Energy Materials, Department of Chemistry",
    "Department of Chemistry"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Mathias R. S. Nielsen"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Stephany Beyerstedt"
    },
    {
      "affs": [
        3,
        1
      ],
      "name": "Rebekka Klemmt"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Espen D. Bøjesen"
    },
    {
      "affs": [
        0,
        1,
        4
      ],
      "name": "Marcos López Hernández"
    },
    {
      "affs": [
        0,
        1,
        4
      ],
      "name": "Jan Skov Pedersen"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Miguel Alexandre Ramos-Docampo",
      "orcid": "0000-0002-2714-0164"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0adxd233xfen4.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15008070/v1",
  "fulltext_url": null,
  "id": "0adxd233xfen4",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008070/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2504|Gold and Silver Nanoparticles Synthesis and Applications"
    ]
  ],
  "openalex": "W7204805816",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15008070/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-31",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/0adxd233xfen4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:17Z",
      "native_id": "10.26434/chemrxiv.15008070",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008070/v2"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2504|Gold and Silver Nanoparticles Synthesis and Applications",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Direct synthesis of high aspect ratio chiral gold nanofibers",
  "title_text": "Direct synthesis of high aspect ratio chiral gold nanofibers",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:19Z",
  "url": "https://research.draconitic.com/paper/0adxd233xfen4",
  "venue": "ChemRxiv",
  "versions": []
}