{
  "abstract": "Evidence on dotinurad, a selective urate transporter 1 inhibitor, in older adults with reduced kidney function is limited. We conducted a retrospective cohort study using the Japan Medical Data Center elderly claims database from April 2021 to February 2023 to describe real-world dotinurad use, one-year prescription presence, and follow-up kidney function data among adults aged ≥ 75 years who underwent health check-ups with serum creatinine measurement. Among 782,897 eligible individuals, 81,674 (10.4%) received urate-lowering therapy. In the mutually exclusive baseline treatment classification, 840 patients (1.0%) were classified into the dotinurad group, whereas patients prescribed multiple urate-lowering therapies were classified separately as combination therapy users. In drug-specific counts, which included combination therapy, any dotinurad prescription was recorded in 1,094 patients, including 106 with eGFR ≤ 30 mL/min/1.73 m². Across the main eGFR categories from 15 to 30 to 60–90 mL/min/1.73 m², one-year prescription records for dotinurad were observed in 72.9–80.9% of drug-specific baseline users. Among 437 patients in the mutually exclusive dotinurad group with follow-up creatinine measurements, mean eGFR changed from 49.8 to 49.7 mL/min/1.73 m² over one year. These findings describe real-world dotinurad use in older adults, but comparative renal effects cannot be inferred.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiology and Nephrology, Mie University Graduate School of Medicine",
    "Department of Infection Control and Infectious Disease Crisis Management, Mie University Graduate School of Medicine",
    "Department of Infection Control and Prevention, Mie University Hospital"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ryosuke Saiki"
    },
    {
      "affs": [
        1
      ],
      "name": "Masaki Tanabe"
    },
    {
      "affs": [
        0
      ],
      "name": "Tomohiro Murata"
    },
    {
      "affs": [
        2
      ],
      "name": "Daisuke Yamasaki"
    },
    {
      "affs": [
        1
      ],
      "name": "Shiho Ito"
    },
    {
      "affs": [
        0
      ],
      "name": "Kan Katayama"
    },
    {
      "affs": [
        0
      ],
      "name": "Kaoru Dohi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0aek1463dn0p7.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-66267-w",
  "fulltext_url": "https://doi.org/10.1038/s41598-026-66267-w",
  "id": "0aek1463dn0p7",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://doi.org/10.1038/s41598-026-66267-w",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "Q"
    ],
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "2727|Gout, Hyperuricemia, Uric Acid"
    ]
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  "openalex": "W7202131175",
  "pdf_url": "https://www.nature.com/articles/s41598-026-66267-w_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-01",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/0aek1463dn0p7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:45:56Z",
      "native_id": "1859ce40e9c04815a7ebf113c8322130",
      "source": "doaj",
      "url": "https://doi.org/10.1038/s41598-026-66267-w"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2727|Gout, Hyperuricemia, Uric Acid",
      "subfield": "general"
    }
  ],
  "title": "Real-world use of dotinurad and one-year prescription presence by kidney function in older adults",
  "title_text": "Real-world use of dotinurad and one-year prescription presence by kidney function in older adults",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:56Z",
  "url": "https://research.draconitic.com/paper/0aek1463dn0p7",
  "venue": "Scientific Reports",
  "versions": []
}