{
  "abstract": "Aims: Pulsed field (PF) ablation is increasingly used to treat paroxysmal atrial fibrillation (PAF). FlexPulse (NCT06676072) was conducted to evaluate safety and effectiveness of a novel dual-energy, flexible-tip focal ablation catheter with radiofrequency and PF for treatment of symptomatic, drug-refractory PAF.\n\nMethods and results: FlexPulse was a global, prospective, single-arm, multicentre study. The ablation procedures targeted pulmonary vein isolation (PVI) and adjunctive ablation at operators’ discretion. The primary safety endpoint was occurrence of pre-defined safety events within 7 days of any ablation procedure. The primary effectiveness endpoint was freedom from a composite of recurrent AF/atrial tachycardia/atrial flutter, repeat procedure, new use or escalation of class I/III AAD, and/or cardioversion through 12-months. Overall, 180 subjects underwent PAF ablation. Successful PVI was achieved in all participants. Additional non-PV ablations were performed in 37.2% (67/180) of subjects. The primary safety endpoint event rate was 1.7%. The primary effectiveness endpoint was 74.6% at 12 months, and freedom from documented AF/AFL/AT recurrence was 77.4% (92.6% without weekly transtelephonic monitoring). In 15 subjects who underwent repeat ablation after the blanking period, remapping indicated that 79.7% (47/59) of the PVs were durably isolated from the index procedures. Retrospective analysis found that workflows with PFA Index (PI) ≥ 30 and AutoMark distance up to 6 mm target had a 12-month freedom from AF/AFL/AT of 84.6%.\n\nConclusion: In this trial, ablation with TactiFlex Duo in patients with symptomatic, drug-refractory PAF was safe and effective.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "name": "Ayman A Hussein",
      "orcid": "0000-0002-8359-1525"
    },
    {
      "name": "Gediminas Rackauskas",
      "orcid": "0000-0003-3272-4380"
    },
    {
      "name": "Sri Sundaram",
      "orcid": "0000-0001-8925-9745"
    },
    {
      "name": "Jonathan P Piccini",
      "orcid": "0000-0003-0772-2404"
    },
    {
      "name": "Franz Xaver Roithinger"
    },
    {
      "name": "Patricia Tung"
    },
    {
      "name": "Jose Osorio",
      "orcid": "0000-0001-7466-123X"
    },
    {
      "name": "B Judson Colley"
    },
    {
      "name": "Usman R Siddiqui"
    },
    {
      "name": "Dhanunjaya R Lakkireddy",
      "orcid": "0000-0002-1492-2693"
    },
    {
      "name": "Larry A Chinitz"
    },
    {
      "name": "Matthew C Hyman",
      "orcid": "0000-0002-4050-6925"
    },
    {
      "name": "Laura Zitella Verbick",
      "orcid": "0000-0003-1359-9916"
    },
    {
      "name": "Nick Dirckx",
      "orcid": "0000-0003-1674-6715"
    },
    {
      "name": "Virginia Woods",
      "orcid": "0000-0003-2635-8396"
    },
    {
      "name": "Monica Lo",
      "orcid": "0000-0001-9054-9010"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0agr4c4jck2fg.bib",
  "cited_by": 1,
  "doi": "10.1093/europace/euag238",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13741632/",
  "id": "0agr4c4jck2fg",
  "issns": [
    "1099-5129",
    "1532-2092"
  ],
  "landing_url": "https://doi.org/10.1093/europace/euag238",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "AcademicSubjects/MED00200"
    ],
    [
      "heading",
      "Clinical Research"
    ],
    [
      "heading",
      "Eurheartj/1"
    ],
    [
      "heading",
      "Eurheartj/3"
    ],
    [
      "heading",
      "Eurheartj/4"
    ],
    [
      "openalex",
      "2705|Atrial Fibrillation Management and Outcomes"
    ]
  ],
  "openalex": "W7204620773",
  "pdf_url": "https://academic.oup.com/europace/advance-article-pdf/doi/10.1093/europace/euag238/70828206/euag238.pdf",
  "pmcid": "PMC13741632",
  "pmid": "42667242",
  "published": "2026-08-28",
  "publisher": "Oxford University Press",
  "ris": "https://research.draconitic.com/paper/0agr4c4jck2fg.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T12:22:38Z",
      "native_id": "PMC13741632",
      "source": "pmc",
      "url": "https://doi.org/10.1093/europace/euag238"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Atrial Fibrillation Management and Outcomes",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Safety and effectiveness of a novel dual-energy radiofrequency/pulsed field ablation catheter: 12-month results of the FlexPulse study",
  "title_text": "Safety and effectiveness of a novel dual-energy radiofrequency/pulsed field ablation catheter: 12-month results of the FlexPulse study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T12:22:38Z",
  "url": "https://research.draconitic.com/paper/0agr4c4jck2fg",
  "venue": "Europace",
  "versions": []
}