{
  "abstract": "微囊藻毒素（MCs）是一类环状七肽毒素，可造成水体污染，并能在水生生物体内富集、沿食物链传递，对人类健康构成严重威胁。然而，环境水样中复杂基质的干扰以及MCs的痕量存在，给其分析检测带来了严峻挑战，亟需开发高效的预处理技术加以克服。本研究利用离子液体介导反应快速聚合制备了一种金属有机框架HKUST-1功能化聚合物整体柱（HKUST-1@poly（DVB-co-AM-co-GMA）），并将其作为毛细管微萃取固定相用于富集水中的MCs。整体柱的制备是以甲基丙烯酸甘油酯（GMA）和丙烯酰胺（AM）为双功能单体，掺杂金属有机框架HKUST-1，以二乙烯苯（DVB）为交联剂，1-己基-3-甲基咪唑四氟硼酸盐（［HMIM］［BF4］）和环己醇为二元致孔剂，热引发聚合而成。表面形貌特征和元素组成表征结果表明，金属有机框架HKUST-1的引入显著增加了整体柱材料的介孔和微孔占比，并提高了比表面积，改善了传统有机聚合物整体柱比表面积小和易溶胀的缺陷，提高了材料对MCs的富集效率。在最优萃取条件下，将HKUST-1功能化整体柱作为毛细管微萃取（CME）的萃取相，与液相色谱-串联质谱（LC-MS/MS）联用，分析环境水样中的3种MCs异构体，检出限为0.28~0.60 ng/L，定量限为0.94~1.99 ng/L，回收率为82.2%~112.0%，相对标准偏差（RSD）不大于7.9%（n=3）。研究表明，借助HKUST-1功能化整体柱提供的特异性金属识别位点、氢键相互作用和π-π相互作用，该方法可高效富集并灵敏检测环境水体中的超痕量MCs，应用前景良好。",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "name": "Junying ZHENG"
    },
    {
      "name": "Hongyan ZENG"
    },
    {
      "name": "Xiaoping WU"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0aqstb923wb07.bib",
  "cited_by": 0,
  "doi": "10.3724/sp.j.1123.2026.01021",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13729053/",
  "id": "0aqstb923wb07",
  "issns": [
    "1000-8713",
    "1872-2059"
  ],
  "landing_url": "https://doi.org/10.3724/sp.j.1123.2026.01021",
  "language": "zh",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Articles"
    ],
    [
      "heading",
      "O658"
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    [
      "heading",
      "a"
    ],
    [
      "openalex",
      "1602|Analytical chemistry methods development"
    ]
  ],
  "openalex": "W7225141229",
  "pdf_url": null,
  "pmcid": "PMC13729053",
  "pmid": "42973226",
  "published": "2026-11-07",
  "publisher": "Editorial Office of Chinese Journal of Chromatography",
  "ris": "https://research.draconitic.com/paper/0aqstb923wb07.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:21:53Z",
      "native_id": "PMC13729053",
      "source": "pmc",
      "url": "https://doi.org/10.3724/sp.j.1123.2026.01021"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1602|Analytical chemistry methods development",
      "subfield": "analytical"
    }
  ],
  "title": "基于金属有机框架HKUST-1功能化聚合物整体柱的环境水样中痕量微囊藻毒素微萃取与分析",
  "title_text": "基于金属有机框架HKUST-1功能化聚合物整体柱的环境水样中痕量微囊藻毒素微萃取与分析",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:21:53Z",
  "url": "https://research.draconitic.com/paper/0aqstb923wb07",
  "venue": "Chinese Journal of Chromatography",
  "versions": []
}