{
  "abstract": "BACKGROUND: Data on asymptomatic deep vein thrombosis (DVT) remain limited. This prospective study investigated the incidence of cancer-associated venous thromboembolism (CA-VTE) in patients receiving cancer treatment with scheduled DVT monitoring. METHODS AND RESULTS: Patients with newly diagnosed locally advanced, recurrent, or metastatic solid cancers without prior VTE were enrolled. Mandatory baseline venous ultrasonography excluded pre-existing DVT. VTE was assessed at Weeks 12, 24, 36, 48, 72, and 96 by lower-extremity ultrasonography, supplemented by contrast-enhanced computed tomography. The primary endpoint was the incidence of CA-VTE within 24 weeks, and a key secondary endpoint was the incidence within 96 weeks. Cox proportional hazards regression was used to explore factors predictive of newly developed VTE. Among 178 patients (median age 68 years; 32% female), the most common primary site of cancer was the gastrointestinal tract (38%). Adenocarcinoma and squamous cell carcinoma each accounted for 43% of enrolled cases. VTE occurred in 23 (12.9%) and 36 (20.2%) patients within 24 and 96 weeks, with most being asymptomatic (91.3% and 69.4%, respectively). CA-VTE incidence did not differ by tumor site or histology, and no predictive factors were identified. Eleven patients required anticoagulation at VTE diagnosis, and 3 further patients required anticoagulation after progression of initially asymptomatic distal DVT. CONCLUSIONS: CA-VTE incidence was alarmingly high, regardless of tumor site or histology. Because anticoagulation was required in a considerable proportion of patients who developed VTE, scheduled DVT monitoring may be warranted.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Shinya Ohata"
    },
    {
      "name": "Yoshinori Imamura"
    },
    {
      "name": "Taku Nose"
    },
    {
      "name": "Kenta Mori"
    },
    {
      "name": "Kazunori Otsui"
    },
    {
      "name": "Takumi Imai"
    },
    {
      "name": "Shiro Kimbara"
    },
    {
      "name": "Yoshiaki Nagatani"
    },
    {
      "name": "Taiji Koyama"
    },
    {
      "name": "Yohei Funakoshi"
    },
    {
      "name": "Naomi Kiyota"
    },
    {
      "name": "Hironobu Minami"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0b69gdnymzjvy.bib",
  "cited_by": 0,
  "doi": "10.1253/circj.cj-26-0016",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_CJ-26-0016/_article",
  "id": "0b69gdnymzjvy",
  "issns": [
    "1347-4820",
    "1346-9843"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_CJ-26-0016/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/cardiovascular"
    ],
    [
      "openalex",
      "2724|Venous Thromboembolism Diagnosis and Management"
    ]
  ],
  "openalex": "W7203789463",
  "pdf_url": "https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_CJ-26-0016/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-20",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/0b69gdnymzjvy.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "10.1253/circj.cj-26-0016",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_CJ-26-0016/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "jstage-journal:medicine/cardiovascular",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Incidence of Cancer-Associated Venous Thromboembolism in Patients With Solid Cancers in Japan ― A Prospective Study ―",
  "title_text": "Incidence of Cancer-Associated Venous Thromboembolism in Patients With Solid Cancers in Japan ― A Prospective Study ―",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/0b69gdnymzjvy",
  "venue": "Circulation Journal",
  "versions": []
}