{
  "abstract": "Transforaminal lumbar interbody fusion (TLIF) has undergone significant evolution toward minimally invasive and endoscopic techniques designed to reduce soft tissue damage while preserving clinical efficacy. The objective of this systematic review and meta-analysis is to compare clinical outcomes and complication rates of biportal endoscopic transforaminal lumbar interbody fusion (BE-TLIF) versus minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) for the treatment of degenerative lumbar disease. We systematically performed a search using PubMed, Ovide MEDLINE, Web of Science, the Cochrane Library, and Google Scholar for peer-reviewed studies up to December 2025. All studies comparing the outcomes between BE-TLIF and MIS-TLIF were included in the Meta-analysis. Quality was assessed using Newcastle-Ottawa Scale. Twenty- two eligible studies including a total of 1,841 patients were included in our meta-analysis. Of these, 881 patients undergoing BE-TLIF and 960 patients undergoing MIS-TLIF. We found that both BE-TLIF and MIS-TLIF procedures had comparable effectiveness with respect to Oswestry Disability Index (ODI) score [standardized mean difference (SMD) -0.12; 95% confidence interval (CI): -0.26 to 0.02, P=0.08], Visual Analog Scale (VAS) Leg score [SMD 0.10 (95% CI: -0.05 to 0.26), P=0.18], fusion rate [OR, 1.33 (95% CI: 0.95 to 1.85), P=0.09], and incidence of overall complications [OR 0.90 (95% CI: 0.64 to 1.26), P=0.55]. However, BE-TLIF was associated with higher risk of dural tear [OR 2.62 (95% CI: 1.34 to 5.12), P=0.005], shorter hospital stays [SMD -0.53 (95% CI: -0.76 to -0.31), P<0.001], and less intraoperative bleeding [SMD -1.56, 95% CI: -2.05 to -1.06), P<0.001], compared to MIS-TLIF. This meta-analysis demonstrates that (BE-TLIF) and (MIS-TLIF) yield comparable clinical efficacy regarding ODI scores, VAS leg scores, fusion rates, and overall complication incidence rate. BE-TLIF was associated with higher risk of dural tear, reduced blood loss and a shorter hospital stay, whereas MIS-TLIF was associated with a shorter operative time. BE-TLIF may therefore be considered for appropriately selected patients, particularly those prioritizing faster postoperative recovery and earlier discharge, while recognizing the potential increased risk of dural tear.",
  "abstract_shown": true,
  "affiliations": [
    "John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.",
    "Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA.",
    "Neuroscience Research Center, Lebanese University, Beirut, Lebanon.",
    "Independent Researcher, Pittsburg, PA, USA.",
    "Excel Health Neurosurgery and Spine, Honolulu, HI, USA.",
    "Department of Mathematics, Cornell University, Ithaca, NY, USA.",
    "Department of Neurological Surgery, University of Rochester Medical Center, Rochester, NY, USA."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Victoria Bieschke"
    },
    {
      "affs": [
        1
      ],
      "name": "Ali Daoud"
    },
    {
      "affs": [
        2
      ],
      "name": "Zeina Nasser"
    },
    {
      "affs": [
        0
      ],
      "name": "Albert H W Jiang"
    },
    {
      "affs": [
        3
      ],
      "name": "Charbel Elias"
    },
    {
      "affs": [
        4
      ],
      "name": "Jeffrey Roh"
    },
    {
      "affs": [
        0
      ],
      "name": "Motoki Tsuneoka"
    },
    {
      "affs": [
        0
      ],
      "name": "Ma Magdalaine Anjeleigh Dela Cruz"
    },
    {
      "affs": [
        0
      ],
      "name": "Anna Peters"
    },
    {
      "affs": [
        0
      ],
      "name": "William J Lew"
    },
    {
      "affs": [
        5
      ],
      "name": "Sabrina Bhalla"
    },
    {
      "affs": [
        4
      ],
      "name": "Thomas Noh"
    },
    {
      "affs": [
        6
      ],
      "name": "Elias Elias"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0b9rtqbymv1ss.bib",
  "cited_by": 0,
  "doi": "10.21037/jss-2026-0209",
  "fulltext_url": "https://europepmc.org/articles/PMC13739633",
  "id": "0b9rtqbymv1ss",
  "issns": [
    "2414-469X",
    "2414-4630"
  ],
  "landing_url": "https://europepmc.org/article/MED/42996526",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2732|Spine and Intervertebral Disc Pathology"
    ]
  ],
  "openalex": "W7223938628",
  "pdf_url": "https://europepmc.org/articles/PMC13739633?pdf=render",
  "pmcid": "PMC13739633",
  "pmid": "42996526",
  "published": "2026-10-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/0b9rtqbymv1ss.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:41Z",
      "native_id": "MED:42996526",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42996526"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2732|Spine and Intervertebral Disc Pathology",
      "subfield": "surgery"
    }
  ],
  "title": "Biportal endoscopic versus minimally invasive transforaminal lumbar interbody fusion for lumbar degenerative disease: a systematic review and meta-analysis.",
  "title_text": "Biportal endoscopic versus minimally invasive transforaminal lumbar interbody fusion for lumbar degenerative disease: a systematic review and meta-analysis.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:41Z",
  "url": "https://research.draconitic.com/paper/0b9rtqbymv1ss",
  "venue": "Journal of spine surgery (Hong Kong)",
  "versions": []
}