{
  "abstract": "Hyperuricemia (HUA) is widespread, and since conventional long-term treatments can be toxic, safer multi-target alternatives are required. Here, we tested a naturally derived synbiotic pairing of the uricolytic probiotic Lactobacillus gasseri SYP-B4432 with a polyphenol-rich Rumex hanus by. extract in a mouse model of hyperuricemia. In just five weeks of daily treatment, the combination reduced serum uric acid by 57.86%, suppressed serum xanthine oxidase activity by 14.31%, and restored the Bacteroidetes/Firmicutes ratio while lowering pro-inflammatory cytokines and attenuating renal histopathology. Importantly, no hepatic/renal impairment or body weight abnormalities were detected, confirming the safety of this intervention. Collectively, the probiotic–herbal duo alleviates HUA through the synergy of three modes of action: curtailing uric acid synthesis (via XOD inhibition), reshaping gut microbiota (to enhance UA excretion), and resolving renal inflammation (via cytokine modulation). This natural, safe, and multi-target synbiotic provides a clinically translatable strategy that may address the side effect limitations of conventional hyperuricemia drugs.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Ying-Ying SHENG"
    },
    {
      "name": "Jia-Hui LV"
    },
    {
      "name": "Liang-Liang ZHU"
    },
    {
      "name": "Meng-Yue ZHANG"
    },
    {
      "name": "Ye LI"
    },
    {
      "name": "Shi-Qiao XU"
    },
    {
      "name": "Da-Wei YANG"
    },
    {
      "name": "Ze-Xu YU"
    },
    {
      "name": "Yi-Xuan ZHANG"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0cc0jf64v9bsg.bib",
  "cited_by": 0,
  "doi": "10.12938/bmfh.2026-029",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/bmfh/45/4/45_2026-029/_article",
  "id": "0cc0jf64v9bsg",
  "issns": [
    "2186-3342"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/bmfh/45/4/45_2026-029/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "biology/microbiology"
    ],
    [
      "openalex",
      "2727|Gout, Hyperuricemia, Uric Acid"
    ]
  ],
  "openalex": "W7168580581",
  "pdf_url": "https://www.jstage.jst.go.jp/article/bmfh/advpub/0/advpub_2026-029/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-08",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/0cc0jf64v9bsg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:35Z",
      "native_id": "10.12938/bmfh.2026-029",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/bmfh/45/4/45_2026-029/_article"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "jstage-journal:biology/microbiology",
      "subfield": "microbiology"
    }
  ],
  "title": "Synergistic effect of a naturally derived Lactobacillus gasseri and Rumex hanus by. extract on alleviating hyperuricemia in mice via uricolysis, gut microbiota modulation, and anti-inflammation",
  "title_text": "Synergistic effect of a naturally derived Lactobacillus gasseri and Rumex hanus by. extract on alleviating hyperuricemia in mice via uricolysis, gut microbiota modulation, and anti-inflammation",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:35Z",
  "url": "https://research.draconitic.com/paper/0cc0jf64v9bsg",
  "venue": "Bioscience of Microbiota, Food and Health",
  "versions": []
}