{
  "abstract": "Background/objectives\n\nCancer remains a serious public health challenge in the United States. Six major cancers (female breast, colorectal, liver, lung/bronchus, pancreas, and prostate) account for a substantial proportion of the national cancer burden. Understanding the changes in the incidence of these cancers over time can provide insights for prevention and control. This study examined temporal trends in the cancer incidence according to age at onset and stage at diagnosis.Methods\n\nThis population-based study analyzed data from the United States Cancer Statistics database for 2001-2023, including all 50 states and the District of Columbia. Joinpoint regression was used to estimate annual percent changes (APCs) and average annual percent changes (AAPCs), with corresponding 95% confidence intervals (CIs), based on age-adjusted incidence rates per 100,000 people. Of note, incidence rates from 2020 data were excluded from the Joinpoint models because COVID-19 pandemic disruptions affected cancer screening, diagnosis, and reporting.Results\n\nFrom 2001 to 2023, the incidence of lung and colorectal cancers declined, particularly among older adults (aged ≥50 years) (lung cancer: AAPC -2.09; 95% CI: -2.27, -1.90; colorectal cancer AAPC -2.70; 95% CI: -2.83, -2.56). In contrast, the incidence of colorectal, pancreatic, and breast cancers increased among younger adults (aged <50 years), whereas the incidence of liver and lung cancer declined. Moreover, prostate cancer incidence declined over time despite modest rebound in recent years (AAPC 1.83; 95% CI: 0.53, 3.14). Stage-specific analyses revealed increasing rates of early-stage diagnoses for several cancers, while late-stage cancer incidence increased for pancreatic and colorectal cancers (especially among younger adults).Conclusions\n\nCancer incidence varied substantially by cancer type, age, and stage at diagnosis. The rising incidence of colorectal, pancreatic, and breast cancers among younger adults underscores the need for continued research into risk factors, early detection, and prevention strategies.",
  "abstract_shown": true,
  "affiliations": [
    "Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.",
    "Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.",
    "Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.",
    "Center for Innovations in Quality, Effectiveness and Safety (IQuESt), Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA.",
    "Texas Medical Center Digestive Disease Center, Houston, TX 77030, USA.",
    "Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, TX 77555, USA."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Itunu Sokale",
      "orcid": "0000-0003-4673-2998"
    },
    {
      "affs": [
        0
      ],
      "name": "Omar Rosales"
    },
    {
      "affs": [
        1,
        2,
        3,
        4
      ],
      "name": "Hashem El-Serag"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Natalia Khalaf",
      "orcid": "0000-0002-7585-6183"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Aaron P Thrift",
      "orcid": "0000-0002-0084-5308"
    },
    {
      "affs": [
        5
      ],
      "name": "Victor Adekanmbi",
      "orcid": "0000-0002-7394-1640"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Abiodun Oluyomi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0cet07ydk8rp4.bib",
  "cited_by": 0,
  "doi": "10.3390/cancers18193149",
  "fulltext_url": "https://europepmc.org/articles/PMC13664070",
  "id": "0cet07ydk8rp4",
  "issns": [
    "2072-6694"
  ],
  "landing_url": "https://europepmc.org/article/MED/42882843",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Global Cancer Incidence and Screening"
    ]
  ],
  "openalex": "W7214794331",
  "pdf_url": "https://europepmc.org/articles/PMC13664070?pdf=render",
  "pmcid": "PMC13664070",
  "pmid": "42882843",
  "published": "2026-09-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/0cet07ydk8rp4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42882843",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42882843"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Global Cancer Incidence and Screening",
      "subfield": "oncology"
    }
  ],
  "title": "Temporal Trends in Six Major Cancers: Implications for Lifestyle-Based Cancer Prevention and Early Detection Across the Life Course.",
  "title_text": "Temporal Trends in Six Major Cancers: Implications for Lifestyle-Based Cancer Prevention and Early Detection Across the Life Course.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/0cet07ydk8rp4",
  "venue": "Cancers",
  "versions": []
}