{
  "abstract": "Western diet (WD)-induced metabolic syndrome (MetS) involves obesity, insulin resistance, dyslipidemia, and low-grade inflammation. While β7 integrin-expressing adaptive immune cells contribute to WD-induced MetS, the role of β7 integrin in innate immunity remains unclear. To address this, the effect of antibody-mediated β7 integrin blockade or β7 integrin deficiency on WD-induced MetS was studied in recombination activating gene-2-deficient mice. Loss or inhibition of β7 integrin protected mice from WD-induced obesity, dyslipidemia, and glucose intolerance, partially via loss of β7 integrin-MAdCAM-1 interactions. β7 integrin deficiency altered intestinal lipid handling and monocyte infiltration into the colon and adipose tissue. Adoptive transfer confirmed that β7-expressing monocytes promote metabolic dysfunction in WD-fed recipients. Phospho-signaling analyses revealed attenuated PI3K-Akt pathway activation in β7 integrin-deficient colonic macrophages, and antibody treatments caused minor shifts in fecal microbiota profiles. Thus, β7 integrin-expressing innate immune cells drive WD-induced metabolic inflammation through monocyte recruitment, macrophage activation, and altered intestinal fat metabolism.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "name": "Sreepradha Eswaran"
    },
    {
      "name": "Agnes Seeger"
    },
    {
      "name": "Sabine Hamm"
    },
    {
      "name": "Kerstin Scheuer"
    },
    {
      "name": "Nicole Treichel"
    },
    {
      "name": "Juliane Hermann"
    },
    {
      "name": "Trong-Hieu Nguyen"
    },
    {
      "name": "Thomas Clavel"
    },
    {
      "name": "Joachim Jankowski"
    },
    {
      "name": "Norbert Wagner"
    },
    {
      "name": "Angela Schippers",
      "orcid": "0000-0003-2132-7486"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0cgb8x8wxyytd.bib",
  "cited_by": 0,
  "doi": "10.1016/j.isci.2026.118042",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13733324/",
  "id": "0cgb8x8wxyytd",
  "issns": [
    "2589-0042"
  ],
  "landing_url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03425-5",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "heading",
      "Cell biology"
    ],
    [
      "heading",
      "Diet"
    ],
    [
      "heading",
      "Immunology"
    ],
    [
      "openalex",
      "1312|Gut microbiota and health"
    ]
  ],
  "openalex": "W7223954358",
  "pdf_url": "https://www.cell.com/iscience/pdf/S2589-0042(26)03425-5.pdf",
  "pmcid": "PMC13733324",
  "pmid": "42985104",
  "published": "2026-10-27",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/0cgb8x8wxyytd.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:16Z",
      "native_id": "10.1016/j.isci.2026.118042",
      "source": "feed-cell",
      "url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03425-5"
    },
    {
      "first_seen": "2026-10-30T12:17:49Z",
      "native_id": "10.1016/j.isci.2026.118042",
      "source": "crossref",
      "url": "https://linkinghub.elsevier.com/retrieve/pii/S2589004226034255"
    },
    {
      "first_seen": "2026-11-08T12:23:08Z",
      "native_id": "PMC13733324",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.isci.2026.118042"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "heading:Cell biology",
      "subfield": "cell-biology"
    },
    {
      "field": "biology",
      "origin": "heading:Immunology",
      "subfield": "immunology"
    }
  ],
  "title": "β7-Integrin worsens diet-induced metabolic syndrome in mice by altering intestinal lipid handling and colonic inflammatory monocyte infiltration",
  "title_text": "β7-Integrin worsens diet-induced metabolic syndrome in mice by altering intestinal lipid handling and colonic inflammatory monocyte infiltration",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:23:08Z",
  "url": "https://research.draconitic.com/paper/0cgb8x8wxyytd",
  "venue": "iScience",
  "versions": []
}