{
  "abstract": "SUMMARY: OBJECTIVE:: Propofol and remifentanil are widely used for elective gastroscopy sedation. The aim of this randomized controlled trial was to compare their safety profiles, patient-reported recovery quality, and endoscopist satisfaction.\n\nMETHODS:: This single-center randomized controlled trial enrolled 88 adults (American Society of Anesthesiologists I–III) undergoing elective gastroscopy, allocated 1:1 to propofol (Group P, n=44) or remifentanil (Group R, n=44). Sedation depth was standardized using the Bispectral Index (target 60–80) and Ramsay Sedation Scale (target 2–3). The primary outcome was the Quality of Recovery-15 score at 30 min post-procedure; secondary outcomes included complication incidence, awakening time, and endoscopist satisfaction.\n\nRESULTS:: Quality of Recovery-15 scores were comparable (median 140 vs. 140; median difference 0, 95%CI -1.0 to 1.0; p=0.95). Total complication incidence was 0% in Group P versus 61.4% in Group R (p<0.001), comprising bradycardia (27.3%), postoperative nausea and vomiting (20.5%), and desaturation (13.6%). Awakening time was shorter in Group R (3 vs. 60 s; p<0.001). Endoscopist satisfaction was significantly higher in Group P (90.9 vs. 56.8% excellent scores; p=0.003).\n\nCONCLUSION:: Despite comparable patient-reported recovery quality, propofol was associated with substantially fewer perioperative adverse events (0 vs. 61.4%) and higher endoscopist satisfaction, supporting its preferential use in routine elective gastroscopy sedation.\n\nClinical Trial Registration Number:: ClinicalTrials.gov, NCT07336628. Registered January 2, 2026.",
  "abstract_shown": true,
  "affiliations": [
    "University of Health Sciences, Fatih Sultan Mehmet Training and Research Hospital, Department of Anesthesiology and Reanimation – Istanbul, Turkiye."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Cansu Ofluoğlu",
      "orcid": "0000-0002-5876-7541"
    },
    {
      "affs": [
        0
      ],
      "name": "Doğa Meriç Yükselen",
      "orcid": "0000-0002-1669-8963"
    },
    {
      "affs": [
        0
      ],
      "name": "Arsen Güngör Ay",
      "orcid": "0000-0003-4021-6052"
    },
    {
      "affs": [
        0
      ],
      "name": "Ayşe Günler Gayretli",
      "orcid": "0009-0007-0236-1060"
    },
    {
      "affs": [
        0
      ],
      "name": "Öznur Demiroluk",
      "orcid": "0000-0002-6427-5148"
    },
    {
      "affs": [
        0
      ],
      "name": "Arzu Yıldırım Ar",
      "orcid": "0000-0002-5867-0897"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0cmqyj2y5n7av.bib",
  "cited_by": 0,
  "doi": "10.1590/1806-9282.20260891",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13711639/?tool=EBI",
  "id": "0cmqyj2y5n7av",
  "issns": [
    "0104-4230",
    "1806-9282"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13711639",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2703|Anesthesia and Sedative Agents"
    ]
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  "openalex": "W7222982128",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13711639/pdf/?tool=EBI",
  "pmcid": "PMC13711639",
  "pmid": "42961227",
  "published": "2026-10-23",
  "publisher": "Associação Médica Brasileira",
  "ris": "https://research.draconitic.com/paper/0cmqyj2y5n7av.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:37Z",
      "native_id": "PMC:PMC13711639",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13711639"
    },
    {
      "first_seen": "2026-10-31T12:22:23Z",
      "native_id": "PMC13711639",
      "source": "pmc",
      "url": "https://doi.org/10.1590/1806-9282.20260891"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2703|Anesthesia and Sedative Agents",
      "subfield": "surgery"
    }
  ],
  "title": "Propofol versus remifentanil sedation for elective gastroscopy: a randomized controlled trial",
  "title_text": "Propofol versus remifentanil sedation for elective gastroscopy: a randomized controlled trial",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T03:21:21Z",
  "url": "https://research.draconitic.com/paper/0cmqyj2y5n7av",
  "venue": "Revista da Associacao Medica Brasileira (1992)",
  "versions": []
}