{
  "abstract": "The Sepia esculenta occupies a significant economic proportion in the squid family, and it is also the squid with the largest economic value in the northern sea area of China. With the occurrence of global warming, ocean acidification and ocean salinity fluctuations, it has caused serious negative effects on the development of the S. esculenta artificial breeding industry. Therefore, in the research, we employed weighted gene co-expression network analysis (WGCNA) to investigate the effects of three environmental factors, including salinity, temperature and pH, on the molecular mechanism of S. esculenta larvae, and proved the reliability of transcriptome results through physiological indicators. Enrichment analysis of each module indicated that environmental exposure markedly influenced immune function, oxidative stress responses, and other physiological processes in S. esculenta larvae. Our research elucidates the comprehensive response mechanism of S. esculenta under different environmental stresses, clarifies the significant molecular pathways essential for its growth and development.",
  "abstract_shown": true,
  "affiliations": [
    "School of Fisheries, Ludong University, Yantai 264025, China; College of Life Sciences, Yantai University, Yantai 264005, China",
    "School of Fisheries, Ludong University, Yantai 264025, China",
    "General Station of Fishery Development and Resource Conservation in Shandong Province, Jinan 250013, China",
    "School of Fisheries, Ludong University, Yantai 264025, China; College of Fisheries and Life Science, Shanghai Ocean University, Shanghai 201306, China",
    "College of Life Sciences, Yantai University, Yantai 264005, China",
    "School of Fisheries, Ludong University, Yantai 264025, China. Electronic address: lizanlxm@163.com"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xueyu Zhu",
      "orcid": "0009-0007-2696-769X"
    },
    {
      "affs": [
        1
      ],
      "name": "Mingzhi Guo"
    },
    {
      "affs": [
        2
      ],
      "name": "Lehai Ni"
    },
    {
      "affs": [
        1
      ],
      "name": "Dan Chang",
      "orcid": "0009-0001-7929-9791"
    },
    {
      "affs": [
        3
      ],
      "name": "Weijun Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Xiaohui Xu"
    },
    {
      "affs": [
        4
      ],
      "name": "Xiumei Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Jianmin Yang"
    },
    {
      "affs": [
        5
      ],
      "name": "Zan Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0d54166h4wvwx.bib",
  "cited_by": 5,
  "doi": "10.1016/j.ygeno.2026.111272",
  "fulltext_url": null,
  "id": "0d54166h4wvwx",
  "issns": [
    "0888-7543",
    "1089-8646"
  ],
  "landing_url": "https://doi.org/10.1016/j.ygeno.2026.111272",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1105|Cephalopods and Marine Biology"
    ]
  ],
  "openalex": "W7163071570",
  "pdf_url": "https://www.sciencedirect.com/science/article/pii/S0888754326000807/pdf",
  "pmcid": null,
  "pmid": "42229771",
  "published": "2026-06-01",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/0d54166h4wvwx.ris",
  "sources": [
    {
      "first_seen": "2026-11-05T13:20:51Z",
      "native_id": "W7163071570",
      "source": "openalex",
      "url": "https://doi.org/10.1016/j.ygeno.2026.111272"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1105|Cephalopods and Marine Biology",
      "subfield": "ecology"
    }
  ],
  "title": "Response mechanism of Sepia esculenta larvae under global warming, ocean acidification and salinity fluctuation: Integrated biochemical and transcriptome profiling",
  "title_text": "Response mechanism of Sepia esculenta larvae under global warming, ocean acidification and salinity fluctuation: Integrated biochemical and transcriptome profiling",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T13:20:45Z",
  "url": "https://research.draconitic.com/paper/0d54166h4wvwx",
  "venue": "Genomics",
  "versions": []
}