{ "abstract": "Background\n\nAdolescent idiopathic scoliosis (AIS) significantly impacts physical appearance and quality of life. This exploratory study aims to investigate potential association between cosmetic parameters and minimal clinical improvement in SRS-22r scores at a 2-year follow-up in AIS patients.Methods\n\nA total of 79 patients were included. Data, including the SRS-22r questionnaire and cosmetic parameters were systematically collected pre- and at 2-year follow-ups. Patients were divided into subgroups based on the Minimal Clinically Important Difference (MCID) values for different domains of the SRS-22r, including Total Improved (TI) and Non-Improved (TNI), Function Improved (FI) and Non-Improved (FNI), Self-image Improved (SI) and Non-Improved (SNI), Pain Improved (PI) and Non-Improved (PNI). Cosmetic corrections (p < 0.05) were included in multivariate regression to explore potential associations with SRS-22r improvement.Results\n\nSignificant differences in Medial Shoulder Tilt (MS), Lateral Shoulder Tilt (LS), Neck Angle (NA), Angle of Trunk Rotation (ATR), Scapula Asymmetry (SA), Waistline Depth Difference (WD), and Waistline Height Distance (WH) were observed pre- and postoperatively. The \"TI\" subgroup showed higher MS correction (1.63 ± 3.17°) than the \"TNI\" subgroup (0.38 ± 1.74°, p = 0.041). The \"FI\" subgroup showed greater ATR correction (4.82 ± 2.83°) than the \"FNI\" subgroup (2.82 ± 3.45°, p = 0.008). WD correction was higher in the \"PI\" subgroup (6.65 ± 8.58 mm) than in the \"PNI\" subgroup (1.93 ± 5.95 mm, p = 0.025). Logistic regression analysis suggested that, in this exploratory model, MS correction was associated with total domain improvement (OR = 1.240, p = 0.037), ATR correction was associated with function domian improvement (OR = 1.204, p = 0.022), and WD correction was associated with pain domain improvement (OR = 1.098, p = 0.017).Conclusions\n\nIn addition to shoulder balance, spinal rotation and waistline asymmetry represent exploratory factors associated with SRS-22r improvement. These findings are hypothesis-generating, as the overall cohort did not achieve MCID thresholds; subgroup analyses explored responder characteristics rather than population-level efficacy.", "abstract_shown": true, "affiliations": [ "Department of Orthopedic Surgery, Peking Union Medical College, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Beijing, 100730, People's Republic of China.", "State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, People's Republic of China.", "Beijing Key Laboratory for Genetic Research of Skeletal Deformity, Beijing, 100730, People's Republic of China.", "Key Laboratory of Big Data for Spinal Deformities, Chinese Academy of Medical Sciences, Beijing, 100730, People's Republic of China.", "Department of spine surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, xinjiang, 830001, People's Republic of China.", "Medical Research Center, Peking Union Medical College, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.", "Department of Orthopedic Surgery, Peking Union Medical College, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Beijing, 100730, People's Republic of China. zbz9639@sina.com.", "Department of Orthopedic Surgery, Peking Union Medical College, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Beijing, 100730, People's Republic of China. jgzhang_pumch@yahoo.com.", "State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, People's Republic of China. jgzhang_pumch@yahoo.com.", "Beijing Key Laboratory for Genetic Research of Skeletal Deformity, Beijing, 100730, People's Republic of China. jgzhang_pumch@yahoo.com.", "Key Laboratory of Big Data for Spinal Deformities, Chinese Academy of Medical Sciences, Beijing, 100730, People's Republic of China. jgzhang_pumch@yahoo.com.", "Department of Orthopedic Surgery, Peking Union Medical College, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Beijing, 100730, People's Republic of China. dr.wunan@pumch.cn.", "State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, People's Republic of China. dr.wunan@pumch.cn.", "Beijing Key Laboratory for Genetic Research of Skeletal Deformity, Beijing, 100730, People's Republic of China. dr.wunan@pumch.cn.", "Key Laboratory of Big Data for Spinal Deformities, Chinese Academy of Medical Sciences, Beijing, 100730, People's Republic of China. dr.wunan@pumch.cn.", "Wenzhou Medical University, Wenzhou, 325035, Zhejiang, People's Republic of China. dr.wunan@pumch.cn." ], "article_type": "research article", "arxiv": null, "author_total": 11, "authors": [ { "affs": [ 0, 1, 2, 3, 4 ], "name": "Aoran Maheshati" }, { "affs": [ 0, 1, 2, 3 ], "name": "Zhengye Zhao" }, { "affs": [ 1, 2, 3, 5 ], "name": "Xueyi Zhang" }, { "affs": [ 0, 1, 2, 3 ], "name": "Di Liu" }, { "affs": [ 0, 1, 2, 3 ], "name": "Guilin Chen" }, { "affs": [ 0, 1, 2, 3 ], "name": "Ziquan Li" }, { "affs": [ 0, 1, 2, 3 ], "name": "Kexin Xu" }, { "affs": [ 0, 1, 2, 3 ], "name": "Qing Li" }, { "affs": [ 6 ], "name": "Baozhong Zhang" }, { "affs": [ 7, 8, 9, 10 ], "name": "Terry Jianguo Zhang" }, { "affs": [ 11, 12, 13, 14, 15 ], "name": "Nan Wu" } ], "bibtex": "https://research.draconitic.com/paper/0d5zk0zhacp23.bib", "cited_by": 1, "doi": "10.1186/s13018-026-07086-7", "fulltext_url": "https://europepmc.org/articles/PMC13726215", "id": "0d5zk0zhacp23", "issns": [ "1749-799X" ], "landing_url": "https://europepmc.org/article/MED/42972391", "language": "eng", "licence": "CC-BY-NC-ND", "licence_label": "CC BY-NC-ND", "licence_source": "article", "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "metadata_licence": null, "native_subjects": [ [ "heading", "Research" ], [ "openalex", "2746|Scoliosis diagnosis and treatment" ] ], "openalex": "W7172482192", "pdf_url": "https://europepmc.org/articles/PMC13726215?pdf=render", "pmcid": "PMC13726215", "pmid": "42972391", "published": "2026-08-05", "publisher": "BMC", "ris": "https://research.draconitic.com/paper/0d5zk0zhacp23.ris", "sources": [ { "first_seen": "2026-11-04T15:20:49Z", "native_id": "MED:42972391", "source": "europepmc", "url": "https://europepmc.org/article/MED/42972391" }, { "first_seen": "2026-11-05T12:22:36Z", "native_id": "PMC13726215", "source": "pmc", "url": "https://doi.org/10.1186/s13018-026-07086-7" } ], "subjects": [ { "field": "medicine", "origin": "openalex:2746|Scoliosis diagnosis and treatment", "subfield": "surgery" } ], "title": "Cosmetic parameters associated with SRS-22r improvement postoperatively in patients with adolescent idiopathic scoliosis: a 2-year follow-up.", "title_text": "Cosmetic parameters associated with SRS-22r improvement postoperatively in patients with adolescent idiopathic scoliosis: a 2-year follow-up.", "type": "peer-reviewed", "updated_at": "2026-11-06T12:22:13Z", "url": "https://research.draconitic.com/paper/0d5zk0zhacp23", "venue": "Journal of orthopaedic surgery and research", "versions": [] }