{
  "abstract": "Poly(ADP-ribose) polymerase inhibitors (PARPi) has improved survival in ovarian cancer (OC), yet its efficacy is severely compromised by the restoration of homologous recombination repair and enhanced drug efflux. Here, we report a reactive oxygen species (ROS)-responsive nanoparticle (DP@NP) for the co-delivery of PARPi and DOT1L inhibitor (DOT1Li) to overcome these limitations through a dual-function mechanism. DP@NP can be triggered by ROS in cancer cells, whereupon the released PARPi induces DNA damage, while DOT1Li augments DNA damage accumulation by suppressing PARPi efflux and impairing DNA repair. This coordinated dual action promotes the accumulation of cytosolic double-stranded DNA, thereby robustly activating the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway. In vivo, DP@NP exhibits efficient tumor targeting and elicits pronounced antitumor activity across multiple OC models. Notably, it remodels the tumor immune microenvironment and upregulates PD-L1, thereby significantly enhancing tumor responsiveness to immune checkpoint inhibitors. This study presents a co-delivery strategy that enhances PARPi efficacy while concurrently promoting antitumor immune activation, offering a viable avenue for the treatment of OC.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Gynecology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China",
    "Beijing National Laboratory for Molecular Sciences, Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China",
    "Faculty of Medicine and Health, Sydney Dental School, The University of Sydney, Sydney, NSW, 2006, Australia",
    "Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia",
    "Suzhou Institute of Pharmaceutical Innovation, Soochow University, Suzhou Industrial Park, No. 218 Xinghu Street, Suzhou City, Jiangsu Province, 215218, China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yi Sun"
    },
    {
      "affs": [
        0
      ],
      "name": "Hongyao Li"
    },
    {
      "affs": [
        0
      ],
      "name": "He Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Hanchen Zhang"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Chun Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Bin Li"
    },
    {
      "affs": [
        4
      ],
      "name": "Haihua Xiao"
    },
    {
      "affs": [
        0
      ],
      "name": "Dan Zhao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0ddhss644z45d.bib",
  "cited_by": 0,
  "doi": "10.1016/j.mtbio.2026.103777",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13738016/",
  "id": "0ddhss644z45d",
  "issns": [
    "2590-0064"
  ],
  "landing_url": "https://doi.org/10.1016/j.mtbio.2026.103777",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review Article"
    ],
    [
      "openalex",
      "2502|Nanoparticle-Based Drug Delivery"
    ]
  ],
  "openalex": "W7223229375",
  "pdf_url": null,
  "pmcid": "PMC13738016",
  "pmid": "42992080",
  "published": "2026-10-23",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/0ddhss644z45d.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:23:05Z",
      "native_id": "PMC13738016",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.mtbio.2026.103777"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Nanoparticle-Based Drug Delivery",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Targeting histone methylation with ROS nanoparticles delivering PARPi prodrugs to amplify the stimulation of cGAS-STING for immunotherapy in ovarian cancer",
  "title_text": "Targeting histone methylation with ROS nanoparticles delivering PARPi prodrugs to amplify the stimulation of cGAS-STING for immunotherapy in ovarian cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:23:05Z",
  "url": "https://research.draconitic.com/paper/0ddhss644z45d",
  "venue": "Materials Today Bio",
  "versions": []
}