{
  "abstract": "Natural compounds are ubiquitously found in the plant kingdom and are well-known for their beneficial effects on human health. The easy accessibility and the relatively affordable price make them popular choices for self-medication and/or as part of a healthy daily diet. While it has long been established that natural compounds can influence the function of drug transporters, information about these interactions is often scattered and fragmented. To more systematically and comprehensively summarize the available information in the related field, we categorized the natural products that affect uptake transporters in the organic anion transporting polypeptide (OATP) and organic anion transporter (OAT) families into three groups: flavonoids, alkaloids, and terpenoids. By providing the half-maximal inhibitory concentration (IC₅₀₎ and/or inhibition constant (K i) of the specific substrates and comparing them to the maximum plasma concentrations (C max) of natural products, the likelihood of drug-drug interactions (DDIs) at these transporters is proposed. Moreover, information regarding mechanistic studies, which is essential for understanding the molecular mechanisms of natural product-transporter interactions but is currently quite limited, is included. We also suggested potential indirect DDIs posed by natural compounds that are mediated by nuclear receptors and protein kinases, which may affect expression and post-translational modification of OATPs and OATs.",
  "abstract_shown": true,
  "affiliations": [
    "Guangdong Laboratory for Lingnan Modern Agriculture, College of Life Sciences, South China Agricultural University, Guangzhou 510642, China.",
    "Guangdong Provincial Key Laboratory for the Development Biology and Environmental Adaptation of Agricultural Organisms, South China Agricultural University, Guangzhou 510642, China."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zichong Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Xuyang Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Chaomin Pan"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Mei Hong"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0dn0e2hkedwwe.bib",
  "cited_by": 0,
  "doi": "10.1016/j.apsb.2026.07.032",
  "fulltext_url": "https://europepmc.org/articles/PMC13712277",
  "id": "0dn0e2hkedwwe",
  "issns": [
    "2211-3835",
    "2211-3843"
  ],
  "landing_url": "https://europepmc.org/article/MED/42948709",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2730|Drug Transport and Resistance Mechanisms"
    ]
  ],
  "openalex": "W7171176719",
  "pdf_url": "https://europepmc.org/articles/PMC13712277?pdf=render",
  "pmcid": "PMC13712277",
  "pmid": "42948709",
  "published": "2026-07-25",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/0dn0e2hkedwwe.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:36Z",
      "native_id": "MED:42948709",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42948709"
    },
    {
      "first_seen": "2026-10-31T12:22:53Z",
      "native_id": "PMC13712277",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.apsb.2026.07.032"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Drug Transport and Resistance Mechanisms",
      "subfield": "oncology"
    }
  ],
  "title": "The interaction of flavonoids, alkaloids, and terpenoids with the major drug transporters in the organic anion transporting polypeptide and organic anion transporter families.",
  "title_text": "The interaction of flavonoids, alkaloids, and terpenoids with the major drug transporters in the organic anion transporting polypeptide and organic anion transporter families.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:22:53Z",
  "url": "https://research.draconitic.com/paper/0dn0e2hkedwwe",
  "venue": "Acta pharmaceutica Sinica. B",
  "versions": []
}