{
  "abstract": "OBJECTIVE: To investigate clinical and microbiological factors associated with persistent faecal carriage of extended spectrum beta-lactamase (ESBL) producing Escherichia coli in infants. METHODS: Between 2010 and 2022, children aged 3 months to 2 years old were sampled in a community setting in France, at two visits, V1 and V2, 3-24 months apart, to screen for prolonged faecal carriage of ESBL-producing E. coli. Patient clinical information and whole genome sequence of each isolate were used for association studies. RESULTS: A total of 4641 children were sampled. 375 (8%) carried an ESBL-producing Enterobacterales, among which 142 of ESBL-producing E. coli carriers were once again sampled at V2 and included in this study. 21.8% (n = 31/142) and 18.4% (n = 16/99) carried the same ESBL-producing E. coli clone for at least 3 and 6 months, respectively. B2 phylogroup, and among which ST131 clones were associated with an increased risk of persistent carriage. Multivariate analysis identified virulence associated genes involved in adhesion (papC/papGII allele and a tia-like gene) and encoding toxin (senB) as major risk factors for persistence. A genome wide association study highlighted the potential role of the frz metabolic operon, known to be involved in enterocytes adhesion/internalisation. CONCLUSION: Main extraintestinal pathogenic E. coli genomic features (phylogenetic background, adhesion properties) are associated with ESBL-producing E. coli gut colonisation persistence in infants, which could potentially lead to an increased risk of febrile urinary tract infection in these patients.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "name": "Gabriel Lignieres"
    },
    {
      "name": "Philippe Bidet"
    },
    {
      "name": "André Birgy"
    },
    {
      "name": "Kevin La"
    },
    {
      "name": "Guillaume Geslain"
    },
    {
      "name": "Erick Denamur"
    },
    {
      "name": "Stéphane Béchet"
    },
    {
      "name": "Olivier Cotto"
    },
    {
      "name": "François Blanquart"
    },
    {
      "name": "Franck Thollot"
    },
    {
      "name": "François Corrard"
    },
    {
      "name": "Céline Courroux"
    },
    {
      "name": "Elsa Sobral"
    },
    {
      "name": "Robert Cohen"
    },
    {
      "name": "Corinne Levy"
    },
    {
      "name": "Stéphane Bonacorsi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0dvgm34zvww27.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ijmm.2026.151734",
  "fulltext_url": null,
  "id": "0dvgm34zvww27",
  "issns": [
    "1438-4221",
    "1618-0607"
  ],
  "landing_url": "https://hal.science/hal-05751934v1",
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1313|Antibiotic Resistance in Bacteria"
    ]
  ],
  "openalex": "W7212276602",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-16",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/0dvgm34zvww27.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:35Z",
      "native_id": "hal-05751934",
      "source": "hal",
      "url": "https://hal.science/hal-05751934v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    }
  ],
  "title": "Prevalence and risk factors for persistent faecal carriage of extended spectrum beta-lactamase producing Escherichia coli in a paediatric community population",
  "title_text": "Prevalence and risk factors for persistent faecal carriage of extended spectrum beta-lactamase producing Escherichia coli in a paediatric community population",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:35Z",
  "url": "https://research.draconitic.com/paper/0dvgm34zvww27",
  "venue": "International Journal of Medical Microbiology",
  "versions": []
}