{
  "abstract": "Poor organelle viability and rapid immune clearance limit mitochondrial transplantation for ischemic disease. Here, we engineer mitochondria-rich cytochalasomes (MRCs) as an intravenously deliverable vesicle platform. MRCs are generated through cytoskeletal remodeling in mesenchymal stem cells. They encapsulate functional mitochondria, protecting them from extracellular stressors and inheriting immunomodulatory proteins, which reduce macrophage phagocytosis by more than sixfold. Mechanistically, MRCs do not fuse with the host mitochondrial network but instead are trafficked to lysosomes and trigger protective autophagy-lysosomal response. In a murine myocardial ischemia/reperfusion (I/R) model, a single intravenous injection of MRCs reduced infarct size by 52% and preserved cardiac function for up to 28 days, whereas isolated mitochondria were ineffective. This work positions MRCs as a promising intravenously deliverable vesicle platform for ischemic heart disease and reveals a non-fusogenic mechanism.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Qidong-Fudan Innovative Institute of Medical Sciences, China.",
    "State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, China.",
    "NHC Key Laboratory of Ischemic Heart Diseases, China.",
    "Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, China.",
    "National Clinical Research Center for Interventional Medicine, Shanghai, China.",
    "Shanxi Medical University, Taiyuan, Shanxi Province, China.",
    "Second Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, China.",
    "Oriental Pan-vascular Devices Innovation College, University of Shanghai for Science and Technology, Shanghai, China.",
    "Institutes of Biomedical Sciences, Fudan University, Shanghai, China.",
    "Zhengzhou Seventh People's Hospital, Zhengzhou, Henan Province, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Xiong Gao",
      "orcid": "0000-0002-4411-7206"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4,
        5,
        6,
        7
      ],
      "name": "Lu Zhang"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Lei Xu"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Yawei Jin"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Benheng Qian"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Yuning Zhang"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
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      "name": "Mohan Li"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Ze Yuan"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Yihua Lu"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Nan Qiu"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Peng Wang"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Xiaolei Sun"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4,
        8
      ],
      "name": "Junbo Ge"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4,
        8,
        9
      ],
      "name": "Aijun Sun"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0e75wkbsjd7nf.bib",
  "cited_by": 0,
  "doi": "10.1016/j.bioactmat.2026.09.036",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13696767/",
  "id": "0e75wkbsjd7nf",
  "issns": [
    "2452-199X"
  ],
  "landing_url": "https://doi.org/10.1016/j.bioactmat.2026.09.036",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
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      "openalex",
      "2502|Nanoparticle-Based Drug Delivery"
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  "openalex": "W7222785088",
  "pdf_url": "https://europepmc.org/articles/PMC13696767?pdf=render",
  "pmcid": "PMC13696767",
  "pmid": "42936108",
  "published": "2026-10-17",
  "publisher": "KeAi Publishing",
  "ris": "https://research.draconitic.com/paper/0e75wkbsjd7nf.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:04Z",
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      "url": "https://doi.org/10.1016/j.bioactmat.2026.09.036"
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  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Nanoparticle-Based Drug Delivery",
      "subfield": "materials-polymers"
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  ],
  "title": "Mitochondria-rich cytochalasomes as an intravenously deliverable vesicle platform for ischemic heart disease",
  "title_text": "Mitochondria-rich cytochalasomes as an intravenously deliverable vesicle platform for ischemic heart disease",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:34:03Z",
  "url": "https://research.draconitic.com/paper/0e75wkbsjd7nf",
  "venue": "Bioactive Materials",
  "versions": []
}