{
  "abstract": "Background. Peripheral artery disease (PAD) is a common and clinically heterogeneous manifestation of systemic atherosclerosis, PAD reflects systemic atherosclerotic burden and confers high cardiovascular morbidity and mortality rates. In Italy, contemporary real-world evidence on diagnostic pathways, adherence to GDMT, use of revascularisation strategies, and on long-term outcomes remains fragmented. Heterogeneous patient pathways, involvement of multiple specialties, and limited number of high-volume centres reduce the feasibility of adequately powered randomised clinical trials across the full clinical disease spectrum. Thus, prospective observational research is essential to generate high-quality, generalisable evidence to guide everyday practice. The START-SIAPAV-PAD registry was designed to describe characteristics, management and clinical history of patients with PAD in Italy. Baseline characteristics and treatment are here reported Methods. START-SIAPAV-PAD is a prospective, multicentre, observational registry enrolling consecutive adults with objectively documented symptomatic PAD managed at 20 Italian Vascular centres. Standardised electronic case-report forms collect demographics, risk factors, comorbidities, haemodynamic parameters, vascular anatomy, medical therapies. Follow-up is planned for a minimum of 3 years. PAD severity is classified according to the Leriche–Fontaine scale, and risk-factor targets follow the 2024 ESC guidelines Results. The present analysis includes 517 patients (72.0% male; median age 71 years) with a high prevalence of hypertension (79.2%), dyslipidaemia (85.0%), diabetes (36.9%), smoking (96.1% current or former) and chronic kidney disease (21.2%). Nearly half reported a walking distance <200 m, 77.5% had a resting ankle–brachial index ≤0.80, and 17.2% presented with Leriche–Fontaine stage IV. Femoropopliteal disease was most frequent (69.8%), with multilevel involvement in 43.4%. Previous revascularisation was common, major amputation was rare. LDL-cholesterol targets (<55 mg/dL) were achieved in 27.9% despite lipid-lowering therapy in 82.1%. Dual pathway inhibition, advanced lipid-lowering therapies, supervised exercise and structured smoking-cessation programmes were insufficiently adopted. Conclusions. In a population with advanced PAD and multiple risk factors we observed a substantial gap between guideline recommendations and real-world practice. Longitudinal follow-up will assess outcomes and opportunities to improve PAD management",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "name": "Elisabetta Favaretto"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0eaq1b8xqzmey.bib",
  "cited_by": 0,
  "doi": null,
  "fulltext_url": "https://www.btvb.org/btvb/article/view/954",
  "id": "0eaq1b8xqzmey",
  "issns": [
    "2785-5309"
  ],
  "landing_url": "https://www.btvb.org/btvb/article/view/954",
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC666-701"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "PAGEPress Publications",
  "ris": "https://research.draconitic.com/paper/0eaq1b8xqzmey.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:47:30Z",
      "native_id": "7a163cc1045e4656889827f8d48ad42d",
      "source": "doaj",
      "url": "https://www.btvb.org/btvb/article/view/954"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RC666-701",
      "subfield": "cardiovascular"
    }
  ],
  "title": "PO138 | THE START-SIAPAV-PAD REGISTRY: RATIONALE, STUDY DESIGN AND BASELINE CHARACTERISTICS OF AN ITALIAN MULTICENTRE REGISTRY",
  "title_text": "PO138 | THE START-SIAPAV-PAD REGISTRY: RATIONALE, STUDY DESIGN AND BASELINE CHARACTERISTICS OF AN ITALIAN MULTICENTRE REGISTRY",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:47:30Z",
  "url": "https://research.draconitic.com/paper/0eaq1b8xqzmey",
  "venue": "Bleeding, Thrombosis and Vascular Biology",
  "versions": []
}