{
  "abstract": "Evidence in Alzheimer’s disease and other dementias shows that changes in cerebrospinal fluid (CSF) turnover and perivascular spaces (PVS) volume are associated with disease progression through impairment of waste-clearance glymphatic pathways. Volume of CSF, PVS, and drainage structures such as venous sinus are mostly excluded in current MRI studies of premanifest synucleinopathy. Here, we used 7 Tesla MRI to investigate whether modifications in CSF, PVS, and venous sinus volumes occur in 18 prodromal synucleinopathy patients (namely isolated rapid-eye-movement sleep behavior disorder, iRBD) compared to 20 healthy young and 18 elderly controls. Our results demonstrated increased CSF and PVS volumes in iRBD without a matching increase in drainage venous structures, as observed in elderly controls. This suggests increased CSF and PVS fluid stasis, possibly due to impaired CSF filtration, a mechanism that could reduce glymphatic function and exacerbate the neurodegenerative process in iRBD.",
  "abstract_shown": true,
  "affiliations": [
    "Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School",
    "Department of Neurology, Massachusetts General Hospital and Harvard Medical School"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Stephan Grimaldi"
    },
    {
      "affs": [
        0
      ],
      "name": "Kavita Singh"
    },
    {
      "affs": [
        0
      ],
      "name": "María Guadalupe García-Gomar"
    },
    {
      "affs": [
        0
      ],
      "name": "Subhranil Koley"
    },
    {
      "affs": [
        0
      ],
      "name": "Firdaus Fabrice Hannanu"
    },
    {
      "affs": [
        0
      ],
      "name": "Ambra Stefani"
    },
    {
      "affs": [
        0
      ],
      "name": "Berkin Bilgic"
    },
    {
      "affs": [
        1
      ],
      "name": "Aleksandar Videnovic"
    },
    {
      "affs": [
        0
      ],
      "name": "Marta Bianciardi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0ebc3ad6bj4v0.bib",
  "cited_by": 0,
  "doi": "10.1038/s41531-026-01444-2",
  "fulltext_url": "https://doi.org/10.1038/s41531-026-01444-2",
  "id": "0ebc3ad6bj4v0",
  "issns": [
    "2373-8057"
  ],
  "landing_url": "https://doi.org/10.1038/s41531-026-01444-2",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC346-429"
    ],
    [
      "openalex",
      "2804|Cerebrospinal fluid and hydrocephalus"
    ]
  ],
  "openalex": "W7166802534",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-01",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/0ebc3ad6bj4v0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:45:44Z",
      "native_id": "4204f69056344bc69bb634a3650c8a23",
      "source": "doaj",
      "url": "https://doi.org/10.1038/s41531-026-01444-2"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2804|Cerebrospinal fluid and hydrocephalus",
      "subfield": "neuroscience"
    }
  ],
  "title": "CSF turnover dysfunction: a hidden early biomarker in iRBD?",
  "title_text": "CSF turnover dysfunction: a hidden early biomarker in iRBD?",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:44Z",
  "url": "https://research.draconitic.com/paper/0ebc3ad6bj4v0",
  "venue": "npj Parkinson's Disease",
  "versions": []
}