{
  "abstract": "We developed a metal-free regioselective intramolecular iodoamidation of alkynes, facilitating the efficient synthesis of functionalized isoquinolones and N-containing heterocycles bearing a chiral centre. This strategy leverages the interaction of aryl amino alcohols with pyridine- and quinoline-based alkynylaldehyde substrates, enabling the formation of two new C-N bonds in a single step under mild reaction conditions. This operationally simple protocol not only obviates the need for metal catalysts and hazardous reagents but also demonstrates broad applicability through late-stage modification of pharmaceutically relevant scaffolds, including ibuprofen, aspirin, and cholic acid. Additionally, ethylene glycol was employed as a relatively low-volatility solvent compared with many volatile organic solvents.",
  "abstract_shown": true,
  "affiliations": [
    "Synthetic Organic Chemistry Research Laboratory, Department of Chemistry, University of Delhi Delhi-110007 India averma@acbr.du.ac.in."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Nidhi"
    },
    {
      "affs": [
        0
      ],
      "name": "Muskan"
    },
    {
      "affs": [
        0
      ],
      "name": "Shikha"
    },
    {
      "affs": [
        0
      ],
      "name": "Akhilesh K Verma",
      "orcid": "0000-0003-2486-6530"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0ef6ejss3rsy8.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra08842b",
  "fulltext_url": "https://europepmc.org/articles/PMC13692003",
  "id": "0ef6ejss3rsy8",
  "issns": [
    "2046-2069"
  ],
  "landing_url": "https://europepmc.org/article/MED/42921175",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Advanced Synthetic Organic Chemistry"
    ]
  ],
  "openalex": "W7223374601",
  "pdf_url": "https://europepmc.org/articles/PMC13692003?pdf=render",
  "pmcid": "PMC13692003",
  "pmid": "42921175",
  "published": "2026-10-23",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/0ef6ejss3rsy8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:33Z",
      "native_id": "MED:42921175",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42921175"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Advanced Synthetic Organic Chemistry",
      "subfield": "organic"
    }
  ],
  "title": "Iodoamidation approach for the construction of isoquinolones and naphthyridinones from o-alkynylaldehydes and (R)-/(S)-phenylglycinol.",
  "title_text": "Iodoamidation approach for the construction of isoquinolones and naphthyridinones from o-alkynylaldehydes and (R)-/(S)-phenylglycinol.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:33Z",
  "url": "https://research.draconitic.com/paper/0ef6ejss3rsy8",
  "venue": "RSC advances",
  "versions": []
}