{
  "abstract": "Wound healing can be severely compromised by infections, particularly those caused by antibiotic-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. We developed antibacterial wound dressings based on electrospun polyvinyl alcohol-chitosan nanofibers containing flame-made silver nanoparticles (Ag NPs). The 2–10 nm Ag NPs are embedded within ∼200 nm fibers, enabling a high and sustained Ag+ ion release with no detectable nanoparticle release, which may help mitigate concerns associated with nanoparticle exposure. Chitosan structurally stabilizes the fibers while modulating swelling and local pH to enhance Ag+ diffusion. The dressings achieved >99.9999% bacterial reduction in vitro and up to 99% ex vivo using freshly excised human skin. Crucially, the dressings maintained >90% viability of human keratinocytes and fibroblasts and showed no detectable impairment of short-term wound healing. This study introduces a scalable, safe-by-design nanofiber platform for infection-resistant and healing-compatible wound care and supports its further evaluation in preclinical studies.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Reshma V. Ramachandran"
    },
    {
      "name": "Jennifer Geara Semaan"
    },
    {
      "name": "Maria Samara"
    },
    {
      "name": "Thomas Thersleff"
    },
    {
      "name": "Matthew Fielden"
    },
    {
      "name": "Pehr Sommar"
    },
    {
      "name": "Ning Xu Landén"
    },
    {
      "name": "Georgios A. Sotiriou",
      "orcid": "0000-0001-5040-620X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0egtf0bampyeb.bib",
  "cited_by": 0,
  "doi": "10.1016/j.isci.2026.117991",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13720824/?tool=EBI",
  "id": "0egtf0bampyeb",
  "issns": [
    "2589-0042"
  ],
  "landing_url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03374-2",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "heading",
      "Bioengineering"
    ],
    [
      "heading",
      "Biomaterials"
    ],
    [
      "heading",
      "Biotechnology"
    ],
    [
      "heading",
      "Materials science"
    ],
    [
      "heading",
      "Tissue engineering"
    ],
    [
      "openalex",
      "2502|Electrospun Nanofibers in Biomedical Applications"
    ]
  ],
  "openalex": "W7223317664",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13720824/pdf/?tool=EBI",
  "pmcid": "PMC13720824",
  "pmid": "42964863",
  "published": "2026-10-23",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/0egtf0bampyeb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:16Z",
      "native_id": "10.1016/j.isci.2026.117991",
      "source": "feed-cell",
      "url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03374-2"
    },
    {
      "first_seen": "2026-10-30T12:17:49Z",
      "native_id": "10.1016/j.isci.2026.117991",
      "source": "crossref",
      "url": "https://linkinghub.elsevier.com/retrieve/pii/S2589004226033742"
    },
    {
      "first_seen": "2026-10-31T12:21:37Z",
      "native_id": "PMC:PMC13720824",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13720824"
    },
    {
      "first_seen": "2026-11-03T12:21:38Z",
      "native_id": "PMC13720824",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.isci.2026.117991"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "heading:Bioengineering",
      "subfield": "systems-synthetic"
    },
    {
      "field": "chemistry",
      "origin": "heading:Materials science",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Chitosan-stabilized electrospun nanofiber dressings with embedded flame-made nanosilver for the treatment of resistant infections",
  "title_text": "Chitosan-stabilized electrospun nanofiber dressings with embedded flame-made nanosilver for the treatment of resistant infections",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:38Z",
  "url": "https://research.draconitic.com/paper/0egtf0bampyeb",
  "venue": "iScience",
  "versions": []
}