{
  "abstract": "Introduction\n\nAlthough overall overdose deaths in the U.S. have plateaued in recent years, there is limited information about how recent changes in the drug landscape have affected people with HIV at regional and national levels. The purpose of this analysis was to describe trends in the cause of death among people with HIV, with a focus on drug-related mortality in this population.Methods\n\nThe authors aggregated cause of death data from HIV surveillance systems in 14 jurisdictions across the U.S. to compare regional trends among people with HIV from 2014 to 2023. Causes of death were categorized as fatal overdose, HIV-related disease, or all other causes based on the underlying ICD-10 codes. Demographic characteristics, HIV care indicators, and substance use trends were also evaluated.Results\n\nAmong people with HIV, the number of overdose deaths increased from 225 in 2014 to 993 in 2023, accounting for 15.6% of all deaths, whereas HIV-related deaths declined from 1,904 to 1,312, representing 20.6% of all deaths in 2023. In the Pacific Northwest and on the East Coast, overdose deaths surpassed HIV-related deaths in 2023. The proportion of overdose deaths among people with HIV attributable to opioids increased in nearly all regions.Conclusions\n\nFatal overdose was a major contributor to mortality among people with HIV and, in some regions, exceeded HIV-related mortality. These findings underscore the importance of overdose prevention for people with HIV, who may benefit from syndemic approaches that integrate HIV care with mental health services, social support, and harm reduction interventions.",
  "abstract_shown": true,
  "affiliations": [
    "Oregon Health Authority, Portland, Oregon",
    "Office of Infectious Disease, Washington State Department of Health, Olympia, Washington",
    "DC Department of Health, Washington, District of Columbia",
    "Minnesota Department of Health, St. Paul, Minnesota",
    "New Jersey Department of Health, Trenton, New Jersey",
    "Michigan Department of Health and Human Services, Lansing, Michigan",
    "Iowa Department of Health and Human Services, Des Moines, Iowa",
    "Division of Epidemiology, Georgia Department of Public Health, Atlanta, Georgia",
    "Tennessee Department of Health, Nashville, Tennessee",
    "Massachusetts Department of Public Health, Boston, Massachusetts",
    "Arizona Department of Health Services, Phoenix, Arizona",
    "New York State Department of Health, Albany, New York",
    "Colorado Department of Public Health and Environment, Denver, Colorado",
    "Division of HIV Health, Philadelphia Department of Public Health, Philadelphia, Pennsylvania"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 20,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Amy I. Zlot"
    },
    {
      "affs": [
        1
      ],
      "name": "Steven Erly"
    },
    {
      "affs": [
        1
      ],
      "name": "Leticia Lawson"
    },
    {
      "affs": [
        2
      ],
      "name": "Kate Drezner"
    },
    {
      "affs": [
        3
      ],
      "name": "Cheryl A. Barber"
    },
    {
      "affs": [
        4
      ],
      "name": "Danica E. Kuncio"
    },
    {
      "affs": [
        4
      ],
      "name": "O. Ena Omoike"
    },
    {
      "affs": [
        5
      ],
      "name": "Janae Benning"
    },
    {
      "affs": [
        6
      ],
      "name": "Alagie Jatta"
    },
    {
      "affs": [
        6
      ],
      "name": "Joyce Mbugua"
    },
    {
      "affs": [
        7
      ],
      "name": "Annabel Nicholas"
    },
    {
      "affs": [
        7
      ],
      "name": "Eleanor Garlow"
    },
    {
      "affs": [
        8
      ],
      "name": "Riley Gulbronson"
    },
    {
      "affs": [
        9
      ],
      "name": "Laura Kersanske"
    },
    {
      "affs": [
        10
      ],
      "name": "Maxwell Short"
    },
    {
      "affs": [
        11
      ],
      "name": "Randall Collura"
    },
    {
      "affs": [
        12
      ],
      "name": "Megan Duffy"
    },
    {
      "affs": [
        13
      ],
      "name": "Melissa M. Kim"
    },
    {
      "affs": [
        13
      ],
      "name": "Kathleen A. Brady"
    },
    {
      "affs": [
        0
      ],
      "name": "Jeff Capizzi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0erz4bhmz170r.bib",
  "cited_by": 0,
  "doi": "10.1016/j.focus.2026.100544",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13753568/?tool=EBI",
  "id": "0erz4bhmz170r",
  "issns": [
    "2773-0654"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13753568",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2713|HIV, Drug Use, Sexual Risk"
    ]
  ],
  "openalex": "W7202265763",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13753568/pdf/?tool=EBI",
  "pmcid": "PMC13753568",
  "pmid": "43017510",
  "published": "2026-08-12",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/0erz4bhmz170r.ris",
  "sources": [
    {
      "first_seen": "2026-11-12T15:23:59Z",
      "native_id": "PMC:PMC13753568",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13753568"
    },
    {
      "first_seen": "2026-11-14T15:20:46Z",
      "native_id": "MED:43017510",
      "source": "europepmc",
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    },
    {
      "first_seen": "2026-11-15T12:22:40Z",
      "native_id": "PMC13753568",
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      "url": "https://doi.org/10.1016/j.focus.2026.100544"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|HIV, Drug Use, Sexual Risk",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Increases in Overdose Deaths Among People With HIV Across 14 U.S. Jurisdictions, 2014–2023",
  "title_text": "Increases in Overdose Deaths Among People With HIV Across 14 U.S. Jurisdictions, 2014–2023",
  "type": "peer-reviewed",
  "updated_at": "2026-11-15T12:22:40Z",
  "url": "https://research.draconitic.com/paper/0erz4bhmz170r",
  "venue": "AJPM focus",
  "versions": []
}