{
  "abstract": "Background/Objectives: Severe acute pancreatitis accounts for 20% of acute pancreatitis episodes and carries a substantial mortality risk. The systematic severity of the disease is driven by a massive cytokine release, with Interleukin-17 (IL-17) acting as a crucial modulator of the pro-inflammatory cascade. This study aimed to evaluate the prognostic value of serum IL-17 at admission and correlate it with multi-organ dysfunctions and clinical-biological outcomes in patients with severe acute pancreatitis. Methods: A retrospective analysis was conducted on a cohort of 35 patients with severe acute pancreatitis. Demographic, etiological, and clinical-biological baseline characteristics were extracted. Serum IL-17 levels were determined at admission using the ELISA method, and data were statistically analyzed. Results: Significantly higher levels of IL-17 were observed in patients who developed multi-organ failure. Prognostic thresholds were identified via ROC analysis to predict organ dysfunctions: ≥19.77 pg/mL for neurological dysfunction (AUC = 0.814, p = 0.003) and acute respiratory distress syndrome (AUC = 0.756, p = 0.024); ≥18.45 pg/mL for respiratory (p = 0.004) and cardiovascular dysfunctions (AUC = 0.820, p = 0.002); and ≥19.81 pg/mL for renal dysfunction (AUC = 0.735, p = 0.020). Furthermore, univariate binary logistic regression identified elevated serum IL-17 as a significant prognostic factor for mortality among patients admitted to the intensive care unit (OR = 1.062, p = 0.048). Conclusions: Serum IL-17 at admission functions as a significant prognostic biomarker that reflects the severe systemic pro-inflammatory status in severe acute pancreatitis and mirrors the risk of subsequent organ dysfunctions and mortality. Incorporating IL-17 into initial risk stratification protocols may assist clinicians in timely therapeutic escalation.",
  "abstract_shown": true,
  "affiliations": [
    "Doctoral School of Medicine, \"Ovidius\" University of Constanta, 900470 Constanta, Romania.",
    "Department of Intensive Care Unit, \"Sf. Apostol Andrei\" Emergency County Hospital, 900591 Constanta, Romania.",
    "Faculty of Medicine, \"Ovidius\" University of Constanta, 900470 Constanta, Romania.",
    "Department of Gastroenterology, \"Sf. Apostol Andrei\" Emergency County Hospital, 900591 Constanta, Romania.",
    "Clinical Service of Pathology, Departments of Pathology, \"Sf. Apostol Andrei\" Emergency County Hospital, 900591 Constanta, Romania.",
    "Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology (CEDMOG), \"Ovidius\" University of Constanta, 900591 Constanta, Romania.",
    "Department of Diabetes, Nutrition and Metabolic Diseases, \"Carol Davila\" University of Medicine and Pharmacy, 020021 Bucharest, Romania.",
    "Department of Diabetes and Metabolic Diseases, \"Prof. N.C. Paulescu\" National Institute of Diabetes, Nutrition and Metabolic Diseases, 020475 Bucharest, Romania.",
    "Department of Oncology, Ovidius Clinical Hospital, 905900 Constanta, Romania."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Diana Iosif"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Viorel Gherghina"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Andra Iulia Suceveanu"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Cristian Ionut Orasanu",
      "orcid": "0000-0001-8039-3200"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Marius Dragos Prazaru"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Iulia Cindea"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Anca Pantea Stoian",
      "orcid": "0000-0003-0555-526X"
    },
    {
      "affs": [
        2,
        8
      ],
      "name": "Laura Mazilu",
      "orcid": "0000-0001-6195-4500"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Alina Doina Nicoara",
      "orcid": "0000-0002-6702-7086"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Adrian Paul Suceveanu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0etvngw1eg86x.bib",
  "cited_by": 0,
  "doi": "10.3390/diseases14100351",
  "fulltext_url": "https://europepmc.org/articles/PMC13702914",
  "id": "0etvngw1eg86x",
  "issns": [
    "2079-9721"
  ],
  "landing_url": "https://europepmc.org/article/MED/42929978",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Pancreatitis Pathology and Treatment"
    ]
  ],
  "openalex": "W7214098538",
  "pdf_url": "https://europepmc.org/articles/PMC13702914?pdf=render",
  "pmcid": "PMC13702914",
  "pmid": "42929978",
  "published": "2026-09-23",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/0etvngw1eg86x.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:01Z",
      "native_id": "MED:42929978",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42929978"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Pancreatitis Pathology and Treatment",
      "subfield": "surgery"
    }
  ],
  "title": "Role of Interleukin 17 in Severe Acute Pancreatitis: Human Retrospective Pilot Study.",
  "title_text": "Role of Interleukin 17 in Severe Acute Pancreatitis: Human Retrospective Pilot Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:01Z",
  "url": "https://research.draconitic.com/paper/0etvngw1eg86x",
  "venue": "Diseases (Basel, Switzerland)",
  "versions": []
}