{
  "abstract": "Introduction: Inflammatory pathways are considered the crossroads of oral cancer and periodontitis. Exosomal microRNAs (miRNAs) have emerged as key regulators linking inflammation and carcinogenesis. Aim: This study aimed to identify differentially expressed miRNAs associated with periodontitis (PD) and evaluate their relevance in head and neck squamous cell carcinoma (HNSCC) using a bioinformatics approach. Materials and methods: miRNA expression data from the GSE89081 dataset (n=10) were analyzed using GEO2R with an adjusted p-value of <0.05. Selected miRNAs were validated in the TCGA-HNSCC dataset via UALCAN, followed by survival analysis. Exosomal localization and target gene prediction were performed using ExoCarta and TargetScan. Results: Among the 25 microRNAs curated from the dataset based on statistical significance, five were significantly expressed in HNSCC and had a notable impact on patient survival. A set of differentially expressed miRNAs was identified, among which hsa-miR-193b-5p and hsa-miR-877-5p were consistently upregulated in both PD and HNSCC datasets. Higher expression levels of these miRNAs were associated with reduced overall survival. Conclusions: The microRNAs, hsa-miR-193b-5p, and hsa-miR-877-5p were significantly upregulated in both datasets. Also, overexpression of these microRNAs was associated with reduced overall survival in patients with HNSCC. Furthermore, low expression of the target transcript of hsa-miR-193b-5p, FLI1, was associated with poor survival in HNSCC patients. These findings suggest a potential role in inflammation-associated carcinogenesis; however, due to the small sample size and in silico design, further experimental validation is warranted.",
  "abstract_shown": true,
  "affiliations": [
    "Clinical Genetics Lab, Centre for Cellular and Molecular Research, Saveetha Dental College and Hospital, SIMATS, Saveetha University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Anitha Pandi"
    },
    {
      "affs": [
        0
      ],
      "name": "Vijayashree Priyadharsini J"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0f4e55h47fcja.bib",
  "cited_by": 0,
  "doi": "10.3897/folmed.68.e181146",
  "fulltext_url": "https://foliamedica.bg/article/181146/download/xml/",
  "id": "0f4e55h47fcja",
  "issns": [
    "1314-2143",
    "0204-8043"
  ],
  "landing_url": "https://doi.org/10.3897/folmed.68.e181146",
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "1306|MicroRNA in disease regulation"
    ]
  ],
  "openalex": "W7224603330",
  "pdf_url": "https://foliamedica.bg/article/181146/download/pdf/",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "Pensoft Publishers",
  "ris": "https://research.draconitic.com/paper/0f4e55h47fcja.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T14:21:11Z",
      "native_id": "1bbdd1486d2f4144ba2dabc004eb197c",
      "source": "doaj",
      "url": "https://doi.org/10.3897/folmed.68.e181146"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|MicroRNA in disease regulation",
      "subfield": "oncology"
    }
  ],
  "title": "Exosomal microRNA signatures in the crossroads of periodontitis and HNSCC",
  "title_text": "Exosomal microRNA signatures in the crossroads of periodontitis and HNSCC",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T14:20:37Z",
  "url": "https://research.draconitic.com/paper/0f4e55h47fcja",
  "venue": "Folia Medica",
  "versions": []
}