{
  "abstract": "Polypseudorotaxane-based polymeric networks provide a versatile framework for constructing injectable hydrogels with dynamic assembly and multifunctional therapeutic capabilities. Herein, we developed an injectable nanocomposite hydrogel (IA@PFHA) based on a polypseudorotaxane network formed through host–guest assembly of α-cyclodextrin-modified hyaluronic acid (HA-αCD) and indocyanine green (ICG)-loaded Pluronic F127 nanoparticles (ICG@PF127), with 2,2′-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride (AIPH) incorporated as an oxygen-independent radical initiator. The resulting network enabled the co-incorporation of ICG and AIPH while exhibiting shear-thinning injectability, providing a polymeric platform for localized integration of photothermal and radical-generating functions. Upon 808 nm irradiation, IA@PFHA generated mild hyperthermia below 45 °C while promoting AIPH-derived radical generation. This design integrates mild photothermal therapy (m-PTT) with oxygen-independent thermodynamic therapy (TDT), thereby addressing the limited thermal stress of mild heating and the therapeutic constraints associated with hypoxic tumor microenvironments. In vitro, IA@PFHA retained its radical-generating capability under hypoxic conditions and enhanced NIR-induced cytotoxicity against CAL 27 cells. In vivo, IA@PFHA combined with NIR irradiation achieved greater tumor growth inhibition than the AIPH-free hydrogel and free formulation, despite comparable photothermal responses among ICG-containing groups. Overall, this study demonstrates a polypseudorotaxane-based polymeric hydrogel platform that integrates complementary photothermal and oxygen-independent radical-generating functions within an injectable network, highlighting the potential of dynamic polymeric network design for localized combination therapy for OSCC.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Central Laboratory, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin 300041, China",
    "Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin Stomatological Hospital, Nankai University, Tianjin 300041, China",
    "Stomatology Institute of Nankai University, Tianjin 300041, China",
    "Department of Oromaxillofacial-Head and Neck Oncology, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin 300041, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Wenjuan Chen"
    },
    {
      "affs": [
        1,
        2,
        3
      ],
      "name": "Hui Lv"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Xiaoyan Zhang"
    },
    {
      "affs": [
        1,
        2,
        3
      ],
      "name": "Jun Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0f7kx8j9m86rh.bib",
  "cited_by": 0,
  "doi": "10.3390/polym18212767",
  "fulltext_url": null,
  "id": "0f7kx8j9m86rh",
  "issns": [
    "2073-4360"
  ],
  "landing_url": "https://www.mdpi.com/2073-4360/18/21/2767",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-06",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/0f7kx8j9m86rh.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T00:21:22Z",
      "native_id": "10.3390/polym18212767",
      "source": "crossref",
      "url": "https://www.mdpi.com/2073-4360/18/21/2767"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "issn:2073-4360",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Injectable Nanocomposite Hydrogel for Enhanced Mild Photothermal Therapy of Oral Cancer via Oxygen-Independent Thermodynamic Therapy",
  "title_text": "Injectable Nanocomposite Hydrogel for Enhanced Mild Photothermal Therapy of Oral Cancer via Oxygen-Independent Thermodynamic Therapy",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T00:21:22Z",
  "url": "https://research.draconitic.com/paper/0f7kx8j9m86rh",
  "venue": "Polymers",
  "versions": []
}