{
  "abstract": "Chronic kidney disease (CKD) associated pruritus (CKD-aP) is a very common condition in end-stage kidney disease under dialysis, affecting up to a third of the patients worldwide,1-2 with a significant impact of their quality of life.3 Until recently, therapeutic solutions were scarce and not very effective.4 The pathogenesis of CKD-aP is multifactorial, involving the accumulation of uremic toxins and inflammatory mediators, abnormal peripheral nerve conduction, and an imbalance between peripheral Mu opioid receptors (MORs) and Kappa opioid receptors (KORs).",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "name": "Guy Rostoker"
    },
    {
      "name": "Antoine Lanot"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0g3vtakxzh6vv.bib",
  "cited_by": 1,
  "doi": "10.1016/j.ekir.2024.01.019",
  "fulltext_url": null,
  "id": "0g3vtakxzh6vv",
  "issns": [
    "2468-0249"
  ],
  "landing_url": "https://hal.science/hal-05746191v1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "0.shs"
    ],
    [
      "openalex",
      "2727|Dialysis and Renal Disease Management"
    ]
  ],
  "openalex": "W4391038026",
  "pdf_url": "http://www.kireports.org/article/S2468024924000202/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-11",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/0g3vtakxzh6vv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:33Z",
      "native_id": "hal-05746191",
      "source": "hal",
      "url": "https://hal.science/hal-05746191v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    }
  ],
  "title": "Contrasting Evolution After Withdrawal of Long-Term Administration of Difelikefalin for CKD-Associated Pruritus",
  "title_text": "Contrasting Evolution After Withdrawal of Long-Term Administration of Difelikefalin for CKD-Associated Pruritus",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:33Z",
  "url": "https://research.draconitic.com/paper/0g3vtakxzh6vv",
  "venue": "Kidney International Reports",
  "versions": []
}