{
  "abstract": "Background: Patients with hematological malignancies undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT) face a higher risk of premature cardiovascular disease that may partly be explained by hypertension. Objectives: The authors studied the prevalence of hypertension in alloHSCT survivors at least 1 year post-transplant. Methods: Two hundred survivors were clinically screened for hypertension. Hypertension was defined according to established ambulatory blood pressure monitoring (ABPM) thresholds. Subclinical vascular damage was assessed through carotid intima-media thickness by ultrasonography of the carotid arteries, pulse wave velocity, and renal function. Results: Of the 200 patients, 168 (84%) completed the 24-hour ABPM. The median age was 57 years (IQR: 46.3-65.0; range: 18-75). Of the 168 patients, 90 patients (53.6%) had hypertension, of which 26 (15.5%) were newly diagnosed, and 56 (33.3%) were untreated. Hypertensive patients by ABPM tended to be older (median 58 [IQR: 49-67] vs 55.5 [IQR: 39.75-64] years; P = 0.060), had a higher intima-media thickness (0.84 ± 0.25 vs 0.76 ± 0.26 mm; P = 0.009), higher pulse wave velocity values (9.0 ± 2.3 vs 7.3 ± 1.6 m/s; P < 0.001), and lower mean estimated glomerular filtration rate (72.3 ± 18.7 vs 80.4 ± 22.5 mL/min/1.73 m 2 ; P = 0.010) compared to normotensive patients. In the logistic regression model, both age in years (OR: 1.03; 95% CI: 1.01-1.05; P = 0.019) and family history of cardiovascular disease and/or premature death (OR: 2.28; 95% CI: 1.17-4.44; P = 0.016) were independently associated with hypertension. Conclusions: Hypertension is highly prevalent, underrecognized, and undertreated in alloHSCT survivors and is cross-sectionally associated with subclinical vascular and renal organ damage.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Hematology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands; University of Groningen, Groningen, the Netherlands",
    "University of Groningen, Groningen, the Netherlands; Division of Vascular Medicine, Department of Internal Medicine, University Medical Centre Groningen, Groningen, the Netherlands",
    "University of Groningen, Groningen, the Netherlands; Department of Laboratory Medicine, University Medical Centre Groningen, Groningen, the Netherlands"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Wejdan Bin Obaid, MD"
    },
    {
      "affs": [
        0
      ],
      "name": "Mar Bellido, MD, PhD"
    },
    {
      "affs": [
        1
      ],
      "name": "Arie M. van Roon, PhD"
    },
    {
      "affs": [
        0
      ],
      "name": "Anouschka Biswana, MSc, MBA"
    },
    {
      "affs": [
        0
      ],
      "name": "Fleurine Meppelink, MSc"
    },
    {
      "affs": [
        2
      ],
      "name": "Michaël V. Lukens, PhD"
    },
    {
      "affs": [
        0
      ],
      "name": "Hilde Kooistra, MD, PhD"
    },
    {
      "affs": [
        0
      ],
      "name": "Goda Choi, MD, PhD"
    },
    {
      "affs": [
        0
      ],
      "name": "Linde Morsink, MD, PhD"
    },
    {
      "affs": [
        0
      ],
      "name": "Carin Hazenberg, MD"
    },
    {
      "affs": [
        0
      ],
      "name": "Gerwin Huls, MD, PhD"
    },
    {
      "affs": [
        1
      ],
      "name": "Joop D. Lefrandt, MD, PhD"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0g8axx4vympgh.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jacadv.2026.103314",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S2772963X26007362",
  "id": "0g8axx4vympgh",
  "issns": [
    "2772-963X"
  ],
  "landing_url": "https://doi.org/10.1016/j.jacadv.2026.103314",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "lcc",
      "RC666-701"
    ],
    [
      "lcc",
      "RC86-88.9"
    ],
    [
      "openalex",
      "2705|Cardiovascular Health and Disease Prevention"
    ]
  ],
  "openalex": "W7214012913",
  "pdf_url": null,
  "pmcid": "PMC13721015",
  "pmid": "42914745",
  "published": "2026-09-22",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/0g8axx4vympgh.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:58Z",
      "native_id": "e0f072cef10f4c7ea59c70a74082b9da",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.jacadv.2026.103314"
    },
    {
      "first_seen": "2026-11-03T12:21:46Z",
      "native_id": "PMC13721015",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.jacadv.2026.103314"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiovascular Health and Disease Prevention",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Hypertension and Subclinical Vascular Damage After Allogeneic Hematopoietic Stem Cell Transplantation",
  "title_text": "Hypertension and Subclinical Vascular Damage After Allogeneic Hematopoietic Stem Cell Transplantation",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:46Z",
  "url": "https://research.draconitic.com/paper/0g8axx4vympgh",
  "venue": "JACC: Advances",
  "versions": []
}