{
  "abstract": "Background\n\nAnkylosing spondylitis (AS) is a chronic inflammatory rheumatic disease characterized by sacroiliitis and spinal osteophyte formation that needs sophisticated testing to improve the accuracy of activity assessment and clinical decision-making.Objective\n\nTo investigate the clinical value of serum amyloid A (SAA) and platelet-to-lymphocyte ratio (PLR) in assessing disease activity in patients with AS.Methods\n\nUsing the bath ankylosing spondylitis disease activity index (BASDAI), 160 AS patients were categorized into 3 subgroups: low activity (BASDAI <4, n = 60), moderate activity (4≤ BASDAI <6, n = 50), and high activity (BASDAI ≥6, n = 50). Quantitative measurements included SAA concentrations and PLR values, with subsequent analysis of their relationship to disease progression. Diagnostic performance was evaluated with receiver operating characteristic (ROC) curve methodology.Results\n\nThe high-activity group showed significantly elevated SAA (48.3 mg/L ± 9.1 mg/L) and PLR (164.5 ± 29.2) versus moderate- (SAA: 29.0 mg/L ± 8.2 mg/L; PLR: 138.4 ± 27.6) and low-activity groups (SAA: 14.3 [11.7-17.2] mg/L; PLR: 102.7 ± 22.2) (all P < 0.001). Both markers correlated strongly with BASDAI (SAA: r = 0.76; PLR: r = 0.71, P < 0.001). ROC analysis demonstrated that an SAA cutoff of 30.6 mg/L predicted high activity (96% sensitivity, 80% specificity), while PLR ≥143.7 showed 78.0% sensitivity and 76.4% specificity. Combined detection achieved superior area under the curve (0.95) versus individual markers (SAA: 0.93; PLR: 0.86).Conclusion\n\nSAA and PLR are strongly associated with BASDAI-defined disease activity in AS, and combined assessment improves identification of high disease activity, supporting their potential role as objective adjunctive markers in clinical assessment.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pain and Rehabilitation, Wuhan Third Hospital Graduate Joint Training Base, School of Medicine , Wuhan University of Science and Technology , ,",
    "Orthopedics Department , Shiyan People's Hospital Affiliated to Hubei University of Medicine , ,",
    "Department of Pain and Rehabilitation, Wuhan Clinical Research Center for Acupotomy Medicine, Wuhan Third Hospital , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "NingNing Yu"
    },
    {
      "affs": [
        1
      ],
      "name": "TaiZhe Wang"
    },
    {
      "affs": [
        2
      ],
      "name": "ZhiGang Liu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0gb534e2ypz8x.bib",
  "cited_by": 1,
  "doi": "10.2478/abm-2026-0027",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13718364/?tool=EBI",
  "id": "0gb534e2ypz8x",
  "issns": [
    "1905-7415",
    "1875-855X"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13718364",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
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      "openalex",
      "2745|Spondyloarthritis Studies and Treatments"
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  "openalex": "W7224273636",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13718364/pdf/?tool=EBI",
  "pmcid": "PMC13718364",
  "pmid": "42960161",
  "published": "2026-08-31",
  "publisher": "De Gruyter",
  "ris": "https://research.draconitic.com/paper/0gb534e2ypz8x.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:37Z",
      "native_id": "PMC:PMC13718364",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13718364"
    },
    {
      "first_seen": "2026-11-01T00:20:52Z",
      "native_id": "MED:42960161",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42960161"
    },
    {
      "first_seen": "2026-11-02T12:22:24Z",
      "native_id": "PMC13718364",
      "source": "pmc",
      "url": "https://doi.org/10.2478/abm-2026-0027"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2745|Spondyloarthritis Studies and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Correlations between serum acute-phase protein SAA, platelet-to-lymphocyte ratio, and disease activity in ankylosing spondylitis",
  "title_text": "Correlations between serum acute-phase protein SAA, platelet-to-lymphocyte ratio, and disease activity in ankylosing spondylitis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:24Z",
  "url": "https://research.draconitic.com/paper/0gb534e2ypz8x",
  "venue": "Asian biomedicine : research, reviews and news",
  "versions": []
}