{
  "abstract": "TLR4-related inflammatory signaling has been implicated in Alzheimer's disease-related immune responses, and TAK-242 has been used as an experimental tool in studies examining this signaling context. This exploratory study characterized inflammatory cytokine and amyloid-associated histological readout patterns associated with TAK-242 exposure in female early-stage APP/PS1 mice. Female APP/PS1 mice were assigned to saline, lipopolysaccharide, or TAK-242 exposure conditions for 6 weeks, with age-matched non-transgenic mice serving as reference controls (n = 8/group). Brain TNF-α, IL-1β, and IL-6 levels were measured by ELISA, and 6E10-positive staining area was quantified by immunohistochemistry. Directional differences in cytokine levels and 6E10-positive staining area were observed between APP/PS1 mice exposed to TAK-242 and untreated APP/PS1 mice. However, because a vehicle-matched APP/PS1 control group was not included, these differences cannot be attributed specifically to TAK-242 and were interpreted as exploratory exposure-associated patterns rather than pharmacological efficacy. This study provides a sex and stage-defined exploratory dataset of inflammatory and amyloid-associated readout patterns in female early-stage APP/PS1 mice to inform future vehicle-controlled investigations.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Radiology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.",
    "School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.",
    "Department of Hematology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.",
    "Department of Neurology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China."
  ],
  "article_type": "brief report",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Xiaolu Ren"
    },
    {
      "affs": [
        0
      ],
      "name": "Ting Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Shan Liu"
    },
    {
      "affs": [
        2
      ],
      "name": "Ling Li"
    },
    {
      "affs": [
        3
      ],
      "name": "Fang Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0gjdmgp0yjmta.bib",
  "cited_by": 0,
  "doi": "10.3389/fnagi.2026.1944097",
  "fulltext_url": "https://europepmc.org/articles/PMC13713749",
  "id": "0gjdmgp0yjmta",
  "issns": [
    "1663-4365"
  ],
  "landing_url": "https://europepmc.org/article/MED/42952777",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Brief Research Report"
    ],
    [
      "openalex",
      "2737|Alzheimer's disease research and treatments"
    ]
  ],
  "openalex": "W7221769196",
  "pdf_url": "https://europepmc.org/articles/PMC13713749?pdf=render",
  "pmcid": "PMC13713749",
  "pmid": "42952777",
  "published": "2026-10-14",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/0gjdmgp0yjmta.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:41Z",
      "native_id": "MED:42952777",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42952777"
    },
    {
      "first_seen": "2026-10-31T12:24:14Z",
      "native_id": "PMC13713749",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fnagi.2026.1944097"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Alzheimer's disease research and treatments",
      "subfield": "physiology"
    }
  ],
  "title": "Sex and stage-defined exploratory inflammatory and amyloid-associated readout patterns in female APP/PS1 mice exposed to TAK-242.",
  "title_text": "Sex and stage-defined exploratory inflammatory and amyloid-associated readout patterns in female APP/PS1 mice exposed to TAK-242.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:21:22Z",
  "url": "https://research.draconitic.com/paper/0gjdmgp0yjmta",
  "venue": "Frontiers in aging neuroscience",
  "versions": []
}