{
  "abstract": "Cosmetic safety assessment increasingly relies on human-relevant nonanimal methods that support mechanistic interpretation and align with a defined decision context. Reconstructed human epidermis (RhE) supports accepted irritation and corrosion procedures. Reconstructed human skin (RhS) and full-thickness equivalents provide tissue-level comparators for dermal architecture, penetration, and recovery. These models are distinct comparator classes. Rather than cataloging skin-on-a-chip (SoC) architectures, this review assigns an appropriate comparator to each cosmetic-safety question. It then defines the residual uncertainty that may justify SoC testing. It also specifies required readouts and evidence thresholds for a prespecified decision. Vascular and immune modules, controlled topical dosing, and multiorgan coupling are considered only when they address unresolved time course, exposure route, tissue context, or mechanism. Decision-ready readouts require traceable calibration, explicit units, prespecified normalization, drift control, variability estimates, comparator agreement, and quantitative acceptance criteria. No reviewed skin SoC has broad regulatory acceptance for routine cosmetic-safety decisions. Translation therefore requires four distinct stages: analytical validation, biological validation, context-of-use qualification, and regulatory acceptance. Current evidence supports SoC mainly as a higher-tier complement when established methods leave a decision-relevant uncertainty.",
  "abstract_shown": true,
  "affiliations": [
    "School of Architectural and Hydraulic Engineering, Jiujiang Polytechnic University of Science and Technology , ,",
    "School of Medicine & Nursing, Huzhou Normal University , No. 759, Erhuan East Road , ,",
    "Institute of Digital Intelligence for Public Health, Huzhou Normal University , No. 759, Erhuan East Road , ,"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Qian Zhu"
    },
    {
      "affs": [
        1
      ],
      "name": "Wenhui Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Xinjie Lv"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Xixi Wu",
      "orcid": "0000-0003-1201-5042"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0h6cwdhvzbycd.bib",
  "cited_by": 0,
  "doi": "10.1021/acsomega.6c08734",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13737838/",
  "id": "0h6cwdhvzbycd",
  "issns": [
    "2470-1343"
  ],
  "landing_url": "https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c08734/5457365/Skin-on-a-Chip-for-Cosmetic-Safety-Assessment-From",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "3404|Animal testing and alternatives"
    ]
  ],
  "openalex": "W7223372424",
  "pdf_url": "https://pubs.acs.org/doi/pdf/10.1021/acsomega.6c08734",
  "pmcid": "PMC13737838",
  "pmid": "42992045",
  "published": "2026-10-23",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/0h6cwdhvzbycd.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:40Z",
      "native_id": "10.1021/acsomega.6c08734",
      "source": "crossref",
      "url": "https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c08734/5457365/Skin-on-a-Chip-for-Cosmetic-Safety-Assessment-From"
    },
    {
      "first_seen": "2026-11-09T12:22:56Z",
      "native_id": "PMC13737838",
      "source": "pmc",
      "url": "https://doi.org/10.1021/acsomega.6c08734"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "issn:2470-1343",
      "subfield": "general"
    }
  ],
  "title": "Skin-on-a-Chip for Cosmetic Safety Assessment: From Reconstructed Skin Models to Regulatory Translation",
  "title_text": "Skin-on-a-Chip for Cosmetic Safety Assessment: From Reconstructed Skin Models to Regulatory Translation",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:56Z",
  "url": "https://research.draconitic.com/paper/0h6cwdhvzbycd",
  "venue": "ACS Omega",
  "versions": []
}