{
  "abstract": "Aspirin is one of the most widely used pharmaceuticals, yet its long-term use is associated with some side effects, including iron-deficiency anemia, which has been mainly linked to the iron-chelating properties of its major metabolite, salicyluric acid (SUA). In this study, the chelating and redox properties of SUA in the presence of iron (Fe³⁺), copper (Cu²⁺), and aluminum (Al³⁺), under neutral pH conditions were investigated using UV-Vis spectrophotometry, Job plot analysis, and ¹H NMR spectroscopy. The stability constants determined for SUA complexes with Cu²⁺ and Al³⁺ were K = 9.9 × 10⁶ and 1.40 × 10⁴ M⁻¹, respectively, classifying SUA as a moderate-affinity chelator. No detectable complexes of SUA with Fe²⁺ or Cu⁺ were observed, indicating selectivity of SUA for higher oxidation states. Competition experiments with the chelating drug deferiprone (L1) confirmed the quantitative displacement of SUA from metal coordination spheres. In a Fenton-initiated lipid peroxidation model using linoleic acid micelles, SUA-copper and iron metal complexes accelerated lipid oxidation, demonstrating pro-oxidant activity. However, the combination of SUA and vitamin C resulted in a net decrease in the lipid peroxidation rate compared to the system containing SUA alone, suggesting a complex interplay between chelation and redox modulation.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Chemical Kinetics & Combustion, 630090 Novosibirsk, Russia.",
    "Department of Physics, Novosibirsk State University, 630090 Novosibirsk, Russia.",
    "Postgraduate Research Institute of Science, Technology, Environment and Medicine, CY-3021 Limassol, Cyprus."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Viktor A Timoshnikov",
      "orcid": "0000-0001-8753-5304"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Aleksandr A Deriskiba",
      "orcid": "0000-0001-7503-000X"
    },
    {
      "affs": [
        0
      ],
      "name": "Vladimir E Koshman"
    },
    {
      "affs": [
        0
      ],
      "name": "Nikolay E Polyakov",
      "orcid": "0000-0002-3666-7750"
    },
    {
      "affs": [
        2
      ],
      "name": "George J Kontoghiorghes",
      "orcid": "0000-0002-3364-7340"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0h79rjxbj8e9d.bib",
  "cited_by": 0,
  "doi": "10.3390/biology15191740",
  "fulltext_url": "https://europepmc.org/articles/PMC13663455",
  "id": "0h79rjxbj8e9d",
  "issns": [
    "2079-7737"
  ],
  "landing_url": "https://europepmc.org/article/MED/42883413",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Metal complexes synthesis and properties"
    ]
  ],
  "openalex": "W7215101684",
  "pdf_url": "https://europepmc.org/articles/PMC13663455?pdf=render",
  "pmcid": "PMC13663455",
  "pmid": "42883413",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/0h79rjxbj8e9d.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42883413",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42883413"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Metal complexes synthesis and properties",
      "subfield": "oncology"
    }
  ],
  "title": "Interactions of Salicyluric Acid with Metal Ions and Ascorbic Acid: Possible Biological and Toxicity Implications in Aspirin Use.",
  "title_text": "Interactions of Salicyluric Acid with Metal Ions and Ascorbic Acid: Possible Biological and Toxicity Implications in Aspirin Use.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/0h79rjxbj8e9d",
  "venue": "Biology",
  "versions": []
}