{
  "abstract": "Objective: Minor ischemic stroke (NIHSS ≤ 5) presents a therapeutic dilemma, balancing the potential benefits of intravenous thrombolysis (IVT) against its hemorrhagic risks, with dual antiplatelet therapy (DAPT) established for recurrence prevention. This meta-analysis compares the efficacy and safety of dual antiplatelet therapy (DAPT) versus intravenous thrombolysis (IVT) in patients with minor stroke, examining functional recovery, the risk of symptomatic intracranial haemorrhage (SICH) and mortality.\n\nMethods: A systematic search of databases was done in PubMed, Embase, Scopus, and Cochrane until June 2025. The studies comparing DAPT and IVT were conducted in patients with minor stroke. Risk ratios (RR) at 95% confidence interval (CI) were pooled with a random-effects model. Heterogeneity was assessed using I2 statistics, and analyses were conducted using RevMan 5.4.\n\nResults: There was no substantial difference between DAPT and IVT in functional recovery i.e., mRS 0-1 (RR, 1.03; 95% CI 0.98-1.09; p = 0.24), mRS 0-2 (RR 1.00; 95% CI 0.98-1.03; p = 0.87). The risk of SICH was significantly lower when using DAPT (RR 0.10; 95% CI 0.03-0.29; p < 0.0001). There was a reduction in mortality that was not statistically significant with DAPT. The stability of results was established by sensitivity analysis.\n\nConclusions: In minor ischemic stroke, DAPT provides similar functional recovery to IVT while offering a significantly improved safety profile through reduced SICH risk. DAPT may represent a safer alternative to thrombolysis in this patient population.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "name": "MUHAMMAD SHOAIB"
    },
    {
      "name": "HASEEB AHMED"
    },
    {
      "name": "AREEB JEHANGIR CHAUDHARY"
    },
    {
      "name": "ABIN ROY"
    },
    {
      "name": "WAFAA DRAO"
    },
    {
      "name": "RIDA-E ZAHRA"
    },
    {
      "name": "ZORAIZ HAIDER"
    },
    {
      "name": "MUHAMMAD SHAMS UL HAQ"
    },
    {
      "name": "ALIZAY FATIMA"
    },
    {
      "name": "SYED HAIDER FAROOQ SHERAZI"
    },
    {
      "name": "AHMED INTAKHAB"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0hsyf1fnrwcp4.bib",
  "cited_by": 0,
  "doi": null,
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13725220/",
  "id": "0hsyf1fnrwcp4",
  "issns": [
    "2759-7504"
  ],
  "landing_url": "https://europepmc.org/article/MED/42973804",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Articles"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://europepmc.org/articles/PMC13725220?pdf=render",
  "pmcid": "PMC13725220",
  "pmid": "42973804",
  "published": "2026-06-05",
  "publisher": "Juntendo Medical Society",
  "ris": "https://research.draconitic.com/paper/0hsyf1fnrwcp4.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:23:39Z",
      "native_id": "PMC13725220",
      "source": "pmc",
      "url": null
    },
    {
      "first_seen": "2026-11-04T15:20:49Z",
      "native_id": "MED:42973804",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42973804"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Comparison of DAPT and Thrombolysis in Minor Stroke with Regard to Efficacy: A Meta-Analysis",
  "title_text": "Comparison of DAPT and Thrombolysis in Minor Stroke with Regard to Efficacy: A Meta-Analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:32Z",
  "url": "https://research.draconitic.com/paper/0hsyf1fnrwcp4",
  "venue": "Juntendo Medical Journal",
  "versions": []
}