{
  "abstract": "Background: Evidence regarding EUS-guided intratumoral phosphorus-32 (P-32) microparticle implantation for locally advanced pancreatic cancer (LAPC) remains limited. This prospective pilot study evaluated its technical feasibility, preliminary safety, and early disease-control outcomes when administered in combination with gemcitabine plus nab-paclitaxel. Methods: Seventeen patients with unresectable LAPC underwent EUS-guided intratumoral P-32 microparticle implantation through a 22-gauge fine-needle aspiration needle during the fourth week of systemic chemotherapy. Intratumoral distribution was assessed using Bremsstrahlung SPECT/CT. Tumour response was evaluated according to RECIST version 1.1, and treatment-emergent adverse events were graded according to CTCAE version 4.0. The main secondary endpoint was local disease control rate at approximately 16 weeks (LDCR16w). All analyses were descriptive. Results: Implantation was technically successful in all 17 patients (100.0%; exact 95% CI, 80.5–100.0%), and SPECT/CT confirmed intratumoral distribution in every case. No implantation-related procedural complications were recorded (0/17; exact 95% CI, 0.0–19.5%). At approximately 16 weeks, CT assessment was available for 16 patients: seven had a partial response and nine had stable disease. The LDCR16w was 16/16 among evaluable patients (100.0%; exact 95% CI, 79.4–100.0%) and 16/17 in the all-treated analysis (94.1%; exact 95% CI, 71.3–99.9%). A reduction in CA19-9 of at least 50% was observed in 13/16 evaluable patients. Four patients underwent subsequent R0 resection (4/17, 23.5%; exact 95% CI, 6.8–49.9%). Adverse events were predominantly grade 1–2; one grade 3 abdominal pain event and no grade 4–5 events were recorded. Only three deaths occurred during a median OS follow-up of 15.6 months, making survival estimates exploratory and statistically immature. Conclusions: In this small, single-center pilot cohort of highly selected patients, EUS-guided intratumoral P-32 microparticle implantation combined with gemcitabine plus nab-paclitaxel was technically feasible and provided preliminary safety information. Because of the absence of a chemotherapy-only comparator, the small sample size, and the limited follow-up, the radiographic, biomarker, resection, and survival outcomes cannot be attributed specifically to P-32 implantation and should be considered descriptive and hypothesis-generating. Larger controlled studies with longer follow-up are required to determine clinical efficacy.",
  "abstract_shown": true,
  "affiliations": [
    "Endoscopy Unit, Gastroenterology Department, Hospital Universitario Río Hortega, 47012 Valladolid, Spain",
    "Medical School of Athens, National and Kapodistrian University of Athens, 11527 Athens, Greece",
    "Gastroenterology Department, Agios Savvas Hospital, 11522 Athens, Greece",
    "First Propaedeutic Department of Surgery, School of Medicine, National and Kapodistrian University of Athens, Hippocration General Hospital of Athens, 11527 Athens, Greece"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Athanasios Kontos",
      "orcid": "0009-0008-7514-0434"
    },
    {
      "affs": [
        1
      ],
      "name": "Ioannis Riris",
      "orcid": "0009-0009-0725-3696"
    },
    {
      "affs": [
        2
      ],
      "name": "Dimitrios Kypraios",
      "orcid": "0009-0009-0515-1215"
    },
    {
      "affs": [
        3
      ],
      "name": "Nikolaos Alexakis",
      "orcid": "0000-0001-7774-054X"
    },
    {
      "affs": [
        3
      ],
      "name": "Georgios Zografos",
      "orcid": "0000-0002-5429-8776"
    },
    {
      "affs": [
        3
      ],
      "name": "Konstantinos Toutouzas",
      "orcid": "0000-0002-7830-6945"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0j0509cy1v2wn.bib",
  "cited_by": 0,
  "doi": "10.3390/cancers18203331",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13702592/?tool=EBI",
  "id": "0j0509cy1v2wn",
  "issns": [
    "2072-6694"
  ],
  "landing_url": "https://www.mdpi.com/2072-6694/18/20/3331",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Pancreatic and Hepatic Oncology Research"
    ]
  ],
  "openalex": "W7204231811",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13702592/pdf/?tool=EBI",
  "pmcid": "PMC13702592",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/0j0509cy1v2wn.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:58Z",
      "native_id": "10.3390/cancers18203331",
      "source": "crossref",
      "url": "https://www.mdpi.com/2072-6694/18/20/3331"
    },
    {
      "first_seen": "2026-10-30T12:21:44Z",
      "native_id": "PMC:PMC13702592",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13702592"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Pancreatic and Hepatic Oncology Research",
      "subfield": "oncology"
    }
  ],
  "title": "Early Local Tumour Control and Feasibility of Intratumoral P-32 Microparticle Implantation in Patients with Locally Advanced Pancreatic Cancer: A Prospective Single-Center Observational Cohort Study",
  "title_text": "Early Local Tumour Control and Feasibility of Intratumoral P-32 Microparticle Implantation in Patients with Locally Advanced Pancreatic Cancer: A Prospective Single-Center Observational Cohort Study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:44Z",
  "url": "https://research.draconitic.com/paper/0j0509cy1v2wn",
  "venue": "Cancers",
  "versions": []
}