{
  "abstract": "Concerns about treatment‐related fertility impairment are common among young adult lymphoma survivors. Evidence on the impact of treatment for aggressive non‐Hodgkin lymphoma (NHL) on future childbearing is limited, although many individuals of reproductive age are affected. This matched cohort study identified male (18–52 years) and female (18–40 years) patients with aggressive NHL between 2007 and 2018 in Sweden and the south‐east health‐care region in Norway, and matched lymphoma‐free comparators. Adjusted hazard ratios (aHRs) comparing childbirth rates in patients treated with primary intensive chemoimmunotherapy (CIT) (e.g., R‐CHOEP and R‐DA‐EPOCH) to standard‐of‐care (R‐CHOP), and to comparators, were estimated using Cox regression. Among 1037 young survivors of aggressive NHL, childbirth rates did not differ significantly by treatment intensity (intensive vs. standard CIT) in females (aHR: 0.61, 95% CI: 0.32–1.13) or males (aHR: 1.20, 95% CI: 0.68–2.09), overall or when stratified by time since diagnosis (< 3 and 3–10 years). However, females treated with intensive CIT had lower childbirth rates than comparators during the first 3 years after diagnosis (aHR: 0.52, 95% CI: 0.30–0.88), but not thereafter (aHR: 1.06, 95% CI: 0.57–1.96). A similar pattern was not seen in males. In Sweden, eight children (three with support from assisted reproductive techniques) were born after stem cell transplantation. In conclusion, childbirth rates did not differ by CIT intensity among survivors of aggressive NHL. Although rates were temporarily reduced in females during the treatment and recovery period after diagnosis, subsequent rates were similar to comparators. These findings provide reassurance, while highlighting the importance of early and ongoing fertility counseling.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Clinical Epidemiology, Department of Medicine Solna Karolinska Institutet Stockholm Sweden",
    "Department of Reproductive Medicine, Division of Gynecology and Reproduction Karolinska University Hospital Stockholm Sweden",
    "Red Door Analytics AB Stockholm Sweden",
    "Department of Immunology, Genetics and Pathology, Cancer Precision Medicine Uppsala University Uppsala Sweden",
    "Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark",
    "Department of Molecular Medicine Aarhus University Hospital Aarhus Denmark",
    "Department of Hematology Aarhus University Hospital Aarhus Denmark",
    "Department of Oncology Oslo University Hospital Oslo Norway",
    "Department of Hematology Karolinska University Hospital Stockholm Sweden"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Stefanie Antonilli",
      "orcid": "0009-0006-0254-5663"
    },
    {
      "affs": [
        1
      ],
      "name": "Anna Marklund"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Joshua Entrop",
      "orcid": "0000-0003-1614-8096"
    },
    {
      "affs": [
        0
      ],
      "name": "Caroline E. Dietrich",
      "orcid": "0000-0001-8231-8183"
    },
    {
      "affs": [
        3
      ],
      "name": "Ingrid Glimelius",
      "orcid": "0000-0001-6158-3041"
    },
    {
      "affs": [
        0,
        4,
        5,
        6
      ],
      "name": "Tarec C. El‐Galaly"
    },
    {
      "affs": [
        7
      ],
      "name": "Alexander Fosså"
    },
    {
      "affs": [
        7
      ],
      "name": "Harald Holte",
      "orcid": "0000-0001-9799-9428"
    },
    {
      "affs": [
        0,
        8
      ],
      "name": "Karin E. Smedby"
    },
    {
      "affs": [
        7
      ],
      "name": "Knut B. Smeland",
      "orcid": "0000-0002-9832-4032"
    },
    {
      "affs": [
        0
      ],
      "name": "Sandra Eloranta",
      "orcid": "0000-0001-5806-0573"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0jc39ef7cepqz.bib",
  "cited_by": 0,
  "doi": "10.1111/ejh.70303",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13729921/",
  "id": "0jc39ef7cepqz",
  "issns": [
    "0902-4441",
    "1600-0609"
  ],
  "landing_url": "https://doi.org/10.1111/ejh.70303",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2743|Reproductive Biology and Fertility"
    ]
  ],
  "openalex": "W7204166835",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ejh.70303",
  "pmcid": "PMC13729921",
  "pmid": "42639856",
  "published": "2026-08-25",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/0jc39ef7cepqz.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:22:38Z",
      "native_id": "PMC13729921",
      "source": "pmc",
      "url": "https://doi.org/10.1111/ejh.70303"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2743|Reproductive Biology and Fertility",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Impact of Intensified Chemoimmunotherapy Regimens in Aggressive Non‐Hodgkin Lymphoma on Reproduction Patterns",
  "title_text": "Impact of Intensified Chemoimmunotherapy Regimens in Aggressive Non‐Hodgkin Lymphoma on Reproduction Patterns",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:38Z",
  "url": "https://research.draconitic.com/paper/0jc39ef7cepqz",
  "venue": "European Journal of Haematology",
  "versions": []
}