{
  "abstract": "Alkyl boronates are a versatile class of organic molecules that have transformed chemical synthesis and had a broad impact in drug discovery, agrochemistry and materials research. For over 50 years, the conventional use of alkyl boronates has been the direct reaction of the C-B bond for the formation of C-C, C-N, C-O and C-X bonds. Here we report the use of alkyl boronates as directing groups to perform site-selective C(sp3)-H functionalization at the distal site. This methodology involves classic Lewis pair chemistry; it uses an alkyl-BF2, generated in situ from alkyl trifluoroborate salts, as a Lewis acid and 2-haloheteroarene as a Lewis base. Under mild photoredox reaction conditions, we are able to site-selectively functionalize the β-position of a wide range of alkyl trifluoroborate salts with the corresponding heteroarene through a cascade sequence of single-electron reduction, hydrogen atom transfer and intramolecular heteroaryl migration. This transformation effectively upgrades alkyl boron compounds into structurally complex heteroarene-containing building blocks.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, Indiana University, Bloomington, IN USA."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Partha Sarathi Hazra",
      "orcid": "0009-0005-2752-9291"
    },
    {
      "affs": [
        0
      ],
      "name": "Makaya Robinson"
    },
    {
      "affs": [
        0
      ],
      "name": "M Kevin Brown",
      "orcid": "0000-0002-4993-0917"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0jfb97cn3a9a0.bib",
  "cited_by": 2,
  "doi": "10.1038/s44160-026-01106-4",
  "fulltext_url": "https://europepmc.org/articles/PMC13739717",
  "id": "0jfb97cn3a9a0",
  "issns": [
    "2731-0582"
  ],
  "landing_url": "https://europepmc.org/article/MED/42996630",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Radical Photochemical Reactions"
    ]
  ],
  "openalex": "W7167933597",
  "pdf_url": "https://europepmc.org/articles/PMC13739717?pdf=render",
  "pmcid": "PMC13739717",
  "pmid": "42996630",
  "published": "2026-07-10",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/0jfb97cn3a9a0.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:42Z",
      "native_id": "MED:42996630",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42996630"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Radical Photochemical Reactions",
      "subfield": "organic"
    }
  ],
  "title": "β-Selective C(sp³)-H functionalization of alkyl boronates using photoredox catalysis.",
  "title_text": "β-Selective C(sp³)-H functionalization of alkyl boronates using photoredox catalysis.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:42Z",
  "url": "https://research.draconitic.com/paper/0jfb97cn3a9a0",
  "venue": "Nature synthesis",
  "versions": []
}