{
  "abstract": "Background\n\nOsteoarthritis (OA) is characterized by progressive articular cartilage degeneration, in which inflammatory mediators drive MMP-mediated matrix breakdown and chondrocyte apoptosis, ultimately leading to pain and functional impairment. Although often described as a \"wear-and-tear\" disease, increasing evidence highlights immune/inflammatory signaling as a key contributor to OA progression. Gastrodia elata Blume (GEB) has reported anti-inflammatory and immunomodulatory activities, but its preventive potential in OA remains unclear. This study evaluated GEB extract in a widely used monosodium iodoacetate (MIA)-induced OA rat model. Male Sprague-Dawley rats (5 weeks old) were assigned to CON, OA, OA + L-GEB, and OA + H-GEB groups; GEB was administered orally once daily for 5 weeks, and OA was induced by intra-articular MIA (3 mg/50 µL) at day 21.Results\n\nGEB improved gross cartilage surface appearance and histopathological outcomes (HE, Safranin O, Alcian blue; Mankin and OARSI scores), showing reduced cartilage damage and better preservation of proteoglycan staining compared with the OA group. Consistently, GEB decreased IL-6, MMP-13, and cleaved caspase-3 in cartilage (IHC) and reduced TUNEL-positive cells, indicating suppression of inflammatory signaling and chondrocyte apoptosis. RT-qPCR further showed downregulation of NF-κB, IL-6, MMP-9, MMP-13, and TIMP-1 mRNA levels in GEB-treated groups versus OA.Conclusions\n\nGEB extract attenuated inflammatory and catabolic responses and inhibited chondrocyte apoptosis in MIA-induced OA, supporting its potential as a prophylactic strategy for localized inflammatory pathology such as osteoarthritis.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biomedical Laboratory Science, Graduate School, Eulji University, Seongnam, Gyeonggi-do, 13156, Republic of Korea.",
    "Department of Biomedical Laboratory Science, Graduate School, Eulji University, Seongnam, Gyeonggi-do, 13156, Republic of Korea. shinjh0157@gmail.com."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yeon Su Lee"
    },
    {
      "affs": [
        0
      ],
      "name": "Da Eun Jung"
    },
    {
      "affs": [
        0
      ],
      "name": "Ji Won Seo"
    },
    {
      "affs": [
        0
      ],
      "name": "Hyeon Jeong Na"
    },
    {
      "affs": [
        0
      ],
      "name": "Jeong Su Park"
    },
    {
      "affs": [
        0
      ],
      "name": "Jin Woo Hong"
    },
    {
      "affs": [
        0
      ],
      "name": "Hyeon Ju Lee"
    },
    {
      "affs": [
        1
      ],
      "name": "Jae-Ho Shin"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0jy71dkjb893n.bib",
  "cited_by": 0,
  "doi": "10.1186/s42826-026-00297-3",
  "fulltext_url": "https://europepmc.org/articles/PMC13685079",
  "id": "0jy71dkjb893n",
  "issns": [
    "1738-6055",
    "2233-7660"
  ],
  "landing_url": "https://europepmc.org/article/MED/42907941",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QH301-705.5"
    ],
    [
      "lcc",
      "R5-920"
    ],
    [
      "openalex",
      "2745|Osteoarthritis Treatment and Mechanisms"
    ]
  ],
  "openalex": "W7223118477",
  "pdf_url": "https://europepmc.org/articles/PMC13685079?pdf=render",
  "pmcid": "PMC13685079",
  "pmid": "42907941",
  "published": "2026-10-21",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/0jy71dkjb893n.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:53Z",
      "native_id": "MED:42907941",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42907941"
    },
    {
      "first_seen": "2026-10-30T13:45:36Z",
      "native_id": "b2037c1ec178475eaa20ea70d5f60769",
      "source": "doaj",
      "url": "https://doi.org/10.1186/s42826-026-00297-3"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2745|Osteoarthritis Treatment and Mechanisms",
      "subfield": "general"
    }
  ],
  "title": "Ameliorative effect of Gastrodia elata Blume extract on inflammation in a rat model of osteoarthritis.",
  "title_text": "Ameliorative effect of Gastrodia elata Blume extract on inflammation in a rat model of osteoarthritis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:36Z",
  "url": "https://research.draconitic.com/paper/0jy71dkjb893n",
  "venue": "Laboratory animal research",
  "versions": []
}