{
  "abstract": "Background: Primary enteric-type adenocarcinoma of the renal parenchyma is an exceptionally rare malignancy, accounting for less than 1% of renal epithelial tumors. Due to its morphological and immunohistochemical overlap with metastatic gastrointestinal malignancy, establishing a primary renal origin presents a considerable diagnostic challenge. Radical nephroureterectomy has traditionally been the standard surgical treatment.\n\nCase presentation: We report a 47-year-old asymptomatic female with an incidental 68 mm cystic-solid left renal mass detected during a trauma evaluation. Imaging suggested Bosniak category IV on computed tomography and cystic teratoma on magnetic resonance imaging. Notably, the patient had bilateral renal malrotation. Serum tumor markers (CEA and CA19-9) were within normal limits. The patient underwent successful robotic-assisted partial nephrectomy with a warm ischemia time of 15 minutes. Histopathology revealed adenocarcinoma with an enteric immunophenotype: positive for CK20, CDX-2, SATB2, and Villin, with complete loss of PAX-8 and GATA-3. Postoperative gastrointestinal endoscopy and ¹⁸ F-FDG PET-CT excluded primary gastrointestinal or distant occult malignancies, confirming a primary renal parenchymal origin. At one-month follow-up, the patient showed no evidence of recurrence without adjuvant therapy.\n\nConclusion: This case represents the first reported association of primary enteric-type renal adenocarcinoma with bilateral renal malrotation and demonstrates that robotic-assisted partial nephrectomy can be a feasible nephron-sparing approach for selected patients with this aggressive tumor. A systematic diagnostic approach including surgical resection, immunohistochemical profiling, and exclusion of gastrointestinal metastasis is essential for accurate diagnosis and optimal management.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Urology, The First Affiliated Hospital of Zhengzhou University"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yuanqi Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Haoke Zheng"
    },
    {
      "affs": [
        0
      ],
      "name": "Gaurab Pokhrel"
    },
    {
      "affs": [
        0
      ],
      "name": "Rongyu Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Shouchang Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Shuanbao Yu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xuepei Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0k0zqt0kth6rk.bib",
  "cited_by": 0,
  "doi": "10.3389/fonc.2026.1977843",
  "fulltext_url": "https://europepmc.org/articles/PMC13713323",
  "id": "0k0zqt0kth6rk",
  "issns": [
    "2234-943X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1977843/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "openalex",
      "2746|Urinary and Genital Oncology Studies"
    ]
  ],
  "openalex": "W7221802784",
  "pdf_url": "https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1977843/pdf",
  "pmcid": "PMC13713323",
  "pmid": "42952572",
  "published": "2026-10-14",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/0k0zqt0kth6rk.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:13Z",
      "native_id": "10.3389/fonc.2026.1977843",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1977843/full"
    },
    {
      "first_seen": "2026-10-31T00:20:34Z",
      "native_id": "MED:42952572",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42952572"
    },
    {
      "first_seen": "2026-10-31T12:23:53Z",
      "native_id": "PMC13713323",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fonc.2026.1977843"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Urinary and Genital Oncology Studies",
      "subfield": "surgery"
    }
  ],
  "title": "Primary enteric-type adenocarcinoma of the renal parenchyma in a patient with bilateral renal malrotation: a case report and review of the literature",
  "title_text": "Primary enteric-type adenocarcinoma of the renal parenchyma in a patient with bilateral renal malrotation: a case report and review of the literature",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:21:01Z",
  "url": "https://research.draconitic.com/paper/0k0zqt0kth6rk",
  "venue": "Frontiers in Oncology",
  "versions": []
}