{
  "abstract": "Illicit drug-related offenses are a rapidly escalating global concern, driving an urgent need for rapid and reliable drug screening systems. Although conventional identification methods provide definitive results, they often require prolonged turnaround times and complex procedures, limiting their utility in point-of-care (POC) applications. Here, we report a roughened gold nanograss (RGNG) surface-enhanced Raman scattering (SERS) substrate designed for sensitive and automated narcotics screening. The hierarchical RGNG architecture, optimized through Au-Ag codeposition followed by selective etching, generates high-density plasmonic hotspots and achieves high analytical sensitivity, even in complex biological matrices. In vivo studies using rat models demonstrated successful classification of four illicit drugs in urine for up to 6 h after administration using principal component analysis. Furthermore, integration with an explainable LightGBM machine learning framework enabled differentiation (AUC = 0.80) of illicit drug-positive samples from heavily medicated negative-control samples across 155 clinical urine specimens by distinguishing drug-associated biomarker patterns from systemic metabolic backgrounds. This diagnostic pipeline, which combines advanced plasmonic engineering with interpretable gradient-boosting algorithms, provides a scalable proof-of-concept approach for rapid forensic and medical screening; external validation in an independent cohort will be required before clinical deployment.",
  "abstract_shown": true,
  "affiliations": [
    "Bionanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.",
    "College of Pharmacy, Daegu Catholic University, 13-13 Hayang-ro, Hayang-eup, Gyeongsan, Gyeongbuk 38430, Republic of Korea.",
    "StoneLab Inc., 205, Daehak-ro 155-gil 10, Yuseong-gu, Daejeon 34138, Republic of Korea.",
    "Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291, Daehak-ro, Yuseong-gu, Daejeon 34051, Republic of Korea.",
    "Department of Nanobiotechnology, KRIBB School, University of Science and Technology (UST), 125 Gwahak-ro, Yuseong-gu, Daejeon 34113, Republic of Korea.",
    "School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.",
    "Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.",
    "Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jinyoung Kim"
    },
    {
      "affs": [
        0
      ],
      "name": "Kang Sik Nam"
    },
    {
      "affs": [
        1
      ],
      "name": "Seongwon Kim"
    },
    {
      "affs": [
        1
      ],
      "name": "Woojin Nam"
    },
    {
      "affs": [
        2
      ],
      "name": "Mingoo Song"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Taejoon Kang",
      "orcid": "0000-0002-5387-6458"
    },
    {
      "affs": [
        0,
        4,
        5
      ],
      "name": "Juyeon Jung"
    },
    {
      "affs": [
        1
      ],
      "name": "Tae Hwan Kim"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Joon Hee Lee"
    },
    {
      "affs": [
        0,
        4,
        5
      ],
      "name": "Eun-Kyung Lim",
      "orcid": "0000-0003-2793-3700"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0k7wtpwzvarvv.bib",
  "cited_by": 0,
  "doi": "10.1021/acsmeasuresciau.6c00234",
  "fulltext_url": "https://europepmc.org/articles/PMC13693224",
  "id": "0k7wtpwzvarvv",
  "issns": [
    "2694-250X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42921410",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2504|Gold and Silver Nanoparticles Synthesis and Applications"
    ]
  ],
  "openalex": "W7214364537",
  "pdf_url": "https://europepmc.org/articles/PMC13693224?pdf=render",
  "pmcid": "PMC13693224",
  "pmid": "42921410",
  "published": "2026-09-24",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/0k7wtpwzvarvv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:36Z",
      "native_id": "MED:42921410",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42921410"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2504|Gold and Silver Nanoparticles Synthesis and Applications",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Interpretable Screening of Illicit Drugs in Raw Urine via LightGBM-Assisted SERS.",
  "title_text": "Interpretable Screening of Illicit Drugs in Raw Urine via LightGBM-Assisted SERS.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:36Z",
  "url": "https://research.draconitic.com/paper/0k7wtpwzvarvv",
  "venue": "ACS measurement science au",
  "versions": []
}