{
  "abstract": "MicroRNAs (miRNAs) are involved in the regulation of glucose metabolism and inflammatory processes associated with type 2 diabetes (T2D) and have potential as biomarkers and therapeutic targets. We analysed the expression of miR-155-5p, miR-141-3p, miR-15b-5p, miR-18a-5p, and miR-379-5p in peripheral blood mononuclear cells (PBMCs) from 79 patients with T2D and 88 non-diabetic controls. Differential expression analysis revealed significant downregulation of miR-15b-5p, miR-155-5p, and miR-18a-5p, and significant upregulation of miR-379-5p in T2D patients. Among the individual miRNAs, miR-15b-5p showed the highest ability to distinguish between T2D and controls (AUC = 0.82, 95% CI 0.76–0.89, p = 0.001). A model combining the four differentially expressed miRNAs (miR-155-5p, miR-15b-5p, miR-18a-5p, and miR-379-5p) with age, sex, and BMI had an AUC of 0.98, compared with 0.93 for age, sex, and BMI alone (p = 0.004, paired DeLong test); the optimism-corrected AUC was 0.97, although the bootstrap procedure did not account for optimism arising from miRNA selection. Functional enrichment analysis identified MAPK, Hippo, FoxO, insulin, AMPK and TGF-β signalling as consistently enriched across analyses based on experimentally supported and predicted miRNA targets.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Biochemistry and Genetics, Ufa Federal Research Centre, Russian Academy of Sciences, 450054 Ufa, Russia",
    "Department of Medical Genetics and Fundamental Medicine, Faculty of General Medicine, Bashkir State Medical University, 450008 Ufa, Russia",
    "Department of Biology, Faculty of Stomatology, Bashkir State Medical University, 450008 Ufa, Russia",
    "Laboratory of Microfluidic Technology, Institute of Fundamental Medicine, Bashkir State Medical University, 450008 Ufa, Russia",
    "Laboratory of Cell Cultures, Institute of Fundamental Medicine, Bashkir State Medical University, 450008 Ufa, Russia",
    "Department of Endocrinology, Faculty of General Medicine, Bashkir State Medical University, 450008 Ufa, Russia",
    "Section of Statistical Multi-Omics, Department of Clinical & Experimental Medicine, School of Biosciences & Medicine, University of Surrey, Guildford GU2 7XH, UK",
    "Department of Psychology, Middlesex University, London NW4 4BT, UK"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yanina Timasheva",
      "orcid": "0000-0002-9918-6962"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Olga Kochetova",
      "orcid": "0000-0002-2944-4428"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Vitaly A. Markelov",
      "orcid": "0000-0002-0663-7219"
    },
    {
      "affs": [
        4
      ],
      "name": "Ksenia V. Danilko"
    },
    {
      "affs": [
        2
      ],
      "name": "Tatyana M. Kochetova"
    },
    {
      "affs": [
        5
      ],
      "name": "Diana Avzaletdinova"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Gulnaz F. Korytina",
      "orcid": "0000-0002-1695-5173"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Zhanna Balkhiyarova",
      "orcid": "0000-0003-3553-7126"
    },
    {
      "affs": [
        7
      ],
      "name": "Arie Nouwen",
      "orcid": "0000-0002-0609-4082"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0k9n5sahjn2bh.bib",
  "cited_by": 0,
  "doi": "10.3390/biom16101503",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13702599/?tool=EBI",
  "id": "0k9n5sahjn2bh",
  "issns": [
    "2218-273X"
  ],
  "landing_url": "https://www.mdpi.com/2218-273X/16/10/1503",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1306|MicroRNA in disease regulation"
    ]
  ],
  "openalex": "W7221958126",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13702599/pdf/?tool=EBI",
  "pmcid": "PMC13702599",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/0k9n5sahjn2bh.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:59Z",
      "native_id": "10.3390/biom16101503",
      "source": "crossref",
      "url": "https://www.mdpi.com/2218-273X/16/10/1503"
    },
    {
      "first_seen": "2026-10-30T12:21:45Z",
      "native_id": "PMC:PMC13702599",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13702599"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|MicroRNA in disease regulation",
      "subfield": "oncology"
    }
  ],
  "title": "Expression Analysis of microRNAs in Peripheral Blood Mononuclear Cells in Type 2 Diabetes",
  "title_text": "Expression Analysis of microRNAs in Peripheral Blood Mononuclear Cells in Type 2 Diabetes",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:45Z",
  "url": "https://research.draconitic.com/paper/0k9n5sahjn2bh",
  "venue": "Biomolecules",
  "versions": []
}