{
  "abstract": "In South Korea, Candidozyma auris is dominated by ear-associated clade II isolates, but institution-based genomic data remain limited. We analysed 35 archived isolates from 29 patients at a tertiary care centre between 2017 and 2023 using antifungal susceptibility testing and whole-genome sequencing. Thirty-four isolates belonged to clade II, and one urine isolate recovered after inter-hospital transfer belonged to subclade Ib. Serial clade II isolates from the same patient clustered together and had lower pairwise SNP distances than different-patient pairs (median, 8.5 versus 181). Among the first isolates from 29 patients, 14 (48.3%) were fluconazole resistant. In first clade II isolates, recurrent curated coding variation was concentrated in TAC1B and ERG11; TAC1B F214S and W198C and ERG11 K143R occurred only in resistant isolates, but recognized coding variants did not account for all resistant isolates. Clade II isolates shared a broadly conserved subtelomeric deletion backbone, with variable chromosome 6 loss of selected glycosylphosphatidylinositol-anchor genes. The clade Ib isolate carried ERG11 Y132F, TAC1B A583S and a CDR1 V704L/E709D-like change and met CDC tentative breakpoints for resistance to fluconazole, amphotericin B and caspofungin. These findings refine the genomic profile of Korean clade II isolates and highlight the potential introduction of a distinct clade I lineage through healthcare transfer.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Laboratory Medicine, Seoul National University Hospital, Seoul, Republic of Korea",
    "Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea",
    "Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jae Hyeon Park",
      "orcid": "0000-0003-0261-2185"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jee-Soo Lee",
      "orcid": "0000-0002-6633-4631"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Seung Won Chae",
      "orcid": "0000-0002-5072-8679"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Taek Soo Kim",
      "orcid": "0000-0002-2093-1721"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Moon-Woo Seong",
      "orcid": "0000-0003-2954-3677"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0kr09gr691z5g.bib",
  "cited_by": 0,
  "doi": "10.1099/mgen.0.001802",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13730534/",
  "id": "0kr09gr691z5g",
  "issns": [
    "2057-5858"
  ],
  "landing_url": "https://doi.org/10.1099/mgen.0.001802",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Pathogens and Epidemiology"
    ],
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2725|Antifungal resistance and susceptibility"
    ]
  ],
  "openalex": "W7225164301",
  "pdf_url": null,
  "pmcid": "PMC13730534",
  "pmid": "42975947",
  "published": "2026-11-03",
  "publisher": "Microbiology Society",
  "ris": "https://research.draconitic.com/paper/0kr09gr691z5g.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:23:04Z",
      "native_id": "PMC13730534",
      "source": "pmc",
      "url": "https://doi.org/10.1099/mgen.0.001802"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2725|Antifungal resistance and susceptibility",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Whole-genome characterization of Candidozyma auris isolates from a Korean tertiary care centre: clade II predominance, partly unexplained fluconazole resistance and a clade I isolate",
  "title_text": "Whole-genome characterization of Candidozyma auris isolates from a Korean tertiary care centre: clade II predominance, partly unexplained fluconazole resistance and a clade I isolate",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:23:04Z",
  "url": "https://research.draconitic.com/paper/0kr09gr691z5g",
  "venue": "Microbial Genomics",
  "versions": []
}