{
  "abstract": "Transforming growth factor-β (TGF-β) signaling is associated with progressive skeletal muscle wasting. It is unknown whether myofibre-specific knockout of TGF-β type I receptors affects muscle transcriptome, mass, contractile force and oxidative metabolism. Here we show that 3 months after myofibre-specific knockout of TGF-β type I receptors (dKO) in male mice, transcriptomics demonstrate substantially more differentially expressed genes in gastrocnemius medialis (GM) than in soleus, mainly related to muscle contraction, hypertrophy and oxidative metabolism. GM mass of dKO mice increases substantially more than maximal force. Conversely, soleus mass of dKO mice increases in proportion to maximal force. Myofibre hypertrophy in dKO mice is accompanied by a proportional increase in succinate dehydrogenase enzyme activity. These adaptations are associated with a simultaneous decrease in β1-syntrophin and increases in sarcolipin, hepatocyte growth factor gene expression and anabolic signalling. Single receptor knockout causes minor phenotypical and transcriptional alterations. Our study highlights that myofibre-specific interference with both TGF-β type I receptors concurrently stimulates myofibre hypertrophy, enhances absolute force and simultaneously augments oxidative capacity.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Prosthodontics, School and Hospital of Stomatology, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University, Guangzhou, China",
    "Laboratory for Myology, Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, The Netherlands",
    "Savid School of Stomatology, Hangzhou Medical College, Hangzhou, China",
    "Department of Oral and Maxillofacial Surgery, Leiden University Medical Center (LUMC), Leiden, The Netherlands",
    "Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Andi Shi"
    },
    {
      "affs": [
        1
      ],
      "name": "Michèle M. G. Hillege"
    },
    {
      "affs": [
        1
      ],
      "name": "Wendy Noort"
    },
    {
      "affs": [
        1
      ],
      "name": "Carla Offringa"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Gang Wu",
      "orcid": "0000-0001-8941-2500"
    },
    {
      "affs": [
        3
      ],
      "name": "Tim Forouzanfar"
    },
    {
      "affs": [
        1,
        4
      ],
      "name": "Willem M. H. Hoogaars"
    },
    {
      "affs": [
        1
      ],
      "name": "Rob C. I. Wüst",
      "orcid": "0000-0003-3781-5177"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Richard T. Jaspers",
      "orcid": "0000-0002-6951-0952"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0ksk6ad1acfg9.bib",
  "cited_by": 1,
  "doi": "10.1038/s42003-026-10501-8",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13728201/",
  "id": "0ksk6ad1acfg9",
  "issns": [
    "2399-3642"
  ],
  "landing_url": "https://doi.org/10.1038/s42003-026-10501-8",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "1312|Muscle Physiology and Disorders"
    ]
  ],
  "openalex": "W4403484394",
  "pdf_url": "https://www.nature.com/articles/s42003-026-10501-8_reference.pdf",
  "pmcid": "PMC13728201",
  "pmid": "42399490",
  "published": "2026-07-03",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/0ksk6ad1acfg9.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T12:23:55Z",
      "native_id": "PMC13728201",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s42003-026-10501-8"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Muscle Physiology and Disorders",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Myofiber-specific knockout of TGF-β type I receptors in mice concurrently drives muscle hypertrophy, oxidative metabolism, and absolute force",
  "title_text": "Myofiber-specific knockout of TGF-β type I receptors in mice concurrently drives muscle hypertrophy, oxidative metabolism, and absolute force",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:21:14Z",
  "url": "https://research.draconitic.com/paper/0ksk6ad1acfg9",
  "venue": "Communications Biology",
  "versions": []
}