{
  "abstract": "Immunosuppressive therapies (ISTs), including calcineurin inhibitors like cyclosporine A (CsA), are essential therapeutics for autoimmunity; however, they often fail and cause dose-limiting toxicity. Severe aplastic anemia (SAA) is a fatal autoimmune bone marrow (BM) failure disorder that is treated with ISTs. BM single-cell RNA sequencing (scRNA-seq) from SAA patients reveals enhanced T cell effector programs, maladaptive myelopoiesis, and impaired inflammation resolution despite standard-of-care therapy, suggesting incomplete restoration of immune homeostasis with ISTs. In murine SAA, CsA improves survival but induces persistent inflammatory T cells, emergency myelopoiesis, and nephrotoxicity following withdrawal. The pro-resolving lipid mediator resolvin E1 (RvE1) similarly prevents SAA-induced mortality but without toxicity or persistent inflammation. Co-treatment with RvE1, concurrently or after CsA, achieves complete survival, restores immune and hematopoietic homeostasis, and reduces toxicity in a ChemR23-dependent manner. These findings support a paradigm shift toward curative therapies that simultaneously engage endogenous repair programs and suppress pathogenic responses to enhance treatment safety and durability.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Immunology and Microbiology, Albany Medical College, Albany, NY 12208, USA",
    "Department of Molecular and Cellular Physiology, Albany Medical College, Albany, NY 12208, USA",
    "Inflammation and Innate Immunity Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institute of Health (NIH), Bethesda, MD 20892, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Rachel Grazda"
    },
    {
      "affs": [
        0
      ],
      "name": "Amber Bahr"
    },
    {
      "affs": [
        0
      ],
      "name": "Lily Nti-kyeremeh"
    },
    {
      "affs": [
        1
      ],
      "name": "Christina Nickerson"
    },
    {
      "affs": [
        1
      ],
      "name": "Gabrielle Fredman"
    },
    {
      "affs": [
        2
      ],
      "name": "Katrin D. Mayer-Barber"
    },
    {
      "affs": [
        0
      ],
      "name": "Katherine C. MacNamara"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0ky5v160bt3yg.bib",
  "cited_by": 0,
  "doi": "10.1016/j.xcrm.2026.103074",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710695/",
  "id": "0ky5v160bt3yg",
  "issns": [
    "2666-3791"
  ],
  "landing_url": "https://doi.org/10.1016/j.xcrm.2026.103074",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "1311|Blood disorders and treatments"
    ]
  ],
  "openalex": "W7214144304",
  "pdf_url": null,
  "pmcid": "PMC13710695",
  "pmid": "42785302",
  "published": "2026-09-24",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/0ky5v160bt3yg.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:36Z",
      "native_id": "PMC13710695",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.xcrm.2026.103074"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Blood disorders and treatments",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Combining pro-resolving therapy with cyclosporine A restores immune homeostasis and reduces toxicity in autoimmune bone marrow failure",
  "title_text": "Combining pro-resolving therapy with cyclosporine A restores immune homeostasis and reduces toxicity in autoimmune bone marrow failure",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:36Z",
  "url": "https://research.draconitic.com/paper/0ky5v160bt3yg",
  "venue": "Cell Reports Medicine",
  "versions": []
}