{
  "abstract": "Viral development links gene expression and genome replication to particle formation within a cell. Here we construct virtual viruses in a JCVI-syn3A-based spatial minimal cell. For mycoplasma virus P1, molecular events connect expression and replication to coarse-grained packaging, followed by a spatial reconstruction of membrane opening and particle release. Individual finite-size particles coexist, move across the boundary and undergo partial crossings and returns before complete exit. In contrast, Acholeplasma phage MV-L1 (L1) expresses its genes and accumulates genomes as the host continues to grow and develops a constricted shape. The coexistence of viral activity and continued host growth is qualitatively consistent with the non-lytic biology of group 1 acholeplasmaviruses. These reconstructions extend the virtual cell to the viruses that develop within it, linking molecular activity, particle behavior and host growth.",
  "abstract_shown": true,
  "affiliations": [
    "Army Medical University"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "W. Sun"
    },
    {
      "name": "Y. Tang"
    },
    {
      "name": "M. Qiu"
    },
    {
      "name": "J. Li"
    },
    {
      "name": "F. Luo"
    },
    {
      "affs": [
        0
      ],
      "name": "C. Dou"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0kzy1qc8kmjh6.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.22.753465",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.22.753465v1.full",
  "id": "0kzy1qc8kmjh6",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.22.753465v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "synthetic biology"
    ],
    [
      "openalex",
      "2303|Bacteriophages and microbial interactions"
    ]
  ],
  "openalex": "W7214112093",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.22.753465v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-22",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/0kzy1qc8kmjh6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:24:02Z",
      "native_id": "10.64898/2026.09.22.753465",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.22.753465v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:synthetic biology",
      "subfield": "systems-synthetic"
    }
  ],
  "title": "Constructing Virtual Viruses in A Spatial Minimal Cell",
  "title_text": "Constructing Virtual Viruses in A Spatial Minimal Cell",
  "type": "preprint",
  "updated_at": "2026-10-30T12:24:02Z",
  "url": "https://research.draconitic.com/paper/0kzy1qc8kmjh6",
  "venue": "bioRxiv",
  "versions": []
}