{
  "abstract": "Pulmonary hypertension (PH) is uncommon in myopathy, encephalopathy, lactic acidosis, and stroke-like (MELAS) and its hemodynamics are poorly described. A 2-year-old Japanese girl was referred to our hospital with PH diagnosed during pneumonia treatment. Cardiac catheterization revealed PH with a high cardiac output. The patient was diagnosed with MELAS based on multiorgan involvement and the detection of an m.3243A>G mutation. PH therapy was partially effective, and oxygen supplementation may help improve PH without worsening the high cardiac output.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Miki Kanai"
    },
    {
      "name": "Hirofumi Tsuru"
    },
    {
      "name": "Takanori Onuki"
    },
    {
      "name": "Shunsuke Nukaga"
    },
    {
      "name": "Shigehito Baba"
    },
    {
      "name": "Masanori Tsukada"
    },
    {
      "name": "Tadaaki Abe"
    },
    {
      "name": "Fujito Numano"
    },
    {
      "name": "Kei Murayama"
    },
    {
      "name": "Akihiko Saitoh"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0m1se0jbcb4gm.bib",
  "cited_by": 0,
  "doi": "10.2169/internalmedicine.7614-26",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7614-26/_article",
  "id": "0m1se0jbcb4gm",
  "issns": [
    "1349-7235",
    "0918-2918"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7614-26/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/general"
    ],
    [
      "openalex",
      "2740|Pulmonary Hypertension Research and Treatments"
    ]
  ],
  "openalex": "W7201831047",
  "pdf_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7614-26/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-08",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/0m1se0jbcb4gm.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "10.2169/internalmedicine.7614-26",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7614-26/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Pulmonary Hypertension Research and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Pulmonary Hypertension with a High-Output Hemodynamic Profile in a Child with MELAS: A Case Report",
  "title_text": "Pulmonary Hypertension with a High-Output Hemodynamic Profile in a Child with MELAS: A Case Report",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:31Z",
  "url": "https://research.draconitic.com/paper/0m1se0jbcb4gm",
  "venue": "Internal Medicine",
  "versions": []
}