{
  "abstract": "Cisplatin (CIS)-induced ovarian toxicity is characterized by follicular depletion, apoptosis, and disruption of intracellular survival signaling. This study investigated whether cycloastragenol (CAG), a telomerase-associated bioactive compound, attenuates CIS-induced ovarian injury in rats. Forty female Sprague-Dawley rats were assigned to two vehicle-control groups and CAG, CIS, or CIS + CAG groups for 15 days. Vehicle controls were pooled after confirming no significant differences. Ovarian morphology and follicle counts were evaluated histologically. Immunohistochemical analyses included PCNA, caspase-3, total FOXO3a, phospho-FOXO3a (Ser253), total mTOR, BAX, BCL-2, and TERT. Serum anti-Müllerian hormone and telomerase-related measurements were assessed by ELISA, and relative telomere length was determined by quantitative real-time PCR. CIS reduced primordial follicle numbers, increased follicular atresia, enhanced BAX expression, reduced BCL-2 and TERT immunoreactivity, and increased the BAX/BCL-2 ratio. CAG co-treatment significantly attenuated the changes in BAX, BCL-2, the BAX/BCL-2 ratio, and TERT. Nuclear phospho-FOXO3a was significantly lower in the CIS + CAG group than in the CIS group, whereas cytoplasmic phospho-FOXO3a did not differ significantly. Total mTOR and caspase-3 were numerically reduced by CAG co-treatment but did not remain significant after multiple-comparison correction. PCNA, total FOXO3a, and serum AMH showed partial or nonsignificant recovery. Relative telomere length did not differ among groups. CAG partially attenuated CIS-induced ovarian injury and apoptotic imbalance and was associated with restoration of ovarian TERT immunoreactivity and modulation of phospho-FOXO3a localization. However, these findings do not establish a causal telomerase-FOXO3a-mTOR mechanism.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Histology and Embryology, Faculty of Medicine, Gazi University, Ankara, Türkiye.",
    "Department of Medical Biology, Faculty of Medicine, Gazi University, Ankara, Türkiye."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Gökçe Nur Arık Erol",
      "orcid": "0000-0003-0129-8358"
    },
    {
      "affs": [
        1
      ],
      "name": "Atiye Seda Yar",
      "orcid": "0000-0002-9201-8464"
    },
    {
      "affs": [
        0
      ],
      "name": "Gülnur Take Kaplanoğlu",
      "orcid": "0000-0002-3661-3488"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0m9vqmdscfaf6.bib",
  "cited_by": 0,
  "doi": "10.1002/jbt.71152",
  "fulltext_url": "https://europepmc.org/articles/PMC13695996",
  "id": "0m9vqmdscfaf6",
  "issns": [
    "1095-6670",
    "1099-0461"
  ],
  "landing_url": "https://europepmc.org/article/MED/42927619",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2739|Reproductive Biology and Fertility"
    ]
  ],
  "openalex": "W7223567423",
  "pdf_url": "https://europepmc.org/articles/PMC13695996?pdf=render",
  "pmcid": "PMC13695996",
  "pmid": "42927619",
  "published": "2026-10-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/0m9vqmdscfaf6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42927619",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42927619"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2739|Reproductive Biology and Fertility",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Cycloastragenol Attenuates Cisplatin-Induced Ovarian Toxicity in Rats: Associations With TERT Expression, Apoptotic Balance, and FOXO3a-mTOR-Related Signaling.",
  "title_text": "Cycloastragenol Attenuates Cisplatin-Induced Ovarian Toxicity in Rats: Associations With TERT Expression, Apoptotic Balance, and FOXO3a-mTOR-Related Signaling.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:18Z",
  "url": "https://research.draconitic.com/paper/0m9vqmdscfaf6",
  "venue": "Journal of biochemical and molecular toxicology",
  "versions": []
}