{
  "abstract": "PER-1-producing Pseudomonas and Acinetobacter and PER-2-producing Enterobacterales, respectively, are increasingly difficult to treat due to combined resistance to antibiotics like ceftazidime, cefiderocol, and ceftazidime/aztreonam-avibactam, among others. PER-14 differs from PER-2 by an S130T substitution. Through combined functional and in silico analyses, we demonstrated that PER-14 is resistant to avibactam and relebactam inhibition while retaining an extended-spectrum activity and the ability to hydrolyze cefiderocol, as the S130T substitution affects the proper binding of the DBOs.",
  "abstract_shown": true,
  "affiliations": [
    "Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Instituto de Investigaciones en Bacteriología y Virología Molecular (IBaViM), Buenos Aires, Argentina",
    "Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina",
    "IQUIR (Instituto de Química Rosario), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Rosario, Rosario, Argentina",
    "Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina",
    "Medical Service, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, USA",
    "GRECC, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, USA",
    "Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA",
    "Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA",
    "Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA",
    "Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA",
    "Department of Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA",
    "CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, Ohio, USA"
  ],
  "article_type": "brief report",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Melina Ruggiero",
      "orcid": "0009-0001-6744-9748"
    },
    {
      "affs": [
        0
      ],
      "name": "Melina García Alonso"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Salvador I. Drusin"
    },
    {
      "affs": [
        0
      ],
      "name": "Roque Figueroa-Espinosa"
    },
    {
      "affs": [
        0
      ],
      "name": "Ivan Jackson Briceño Muñoz"
    },
    {
      "affs": [
        4,
        5,
        6,
        7,
        8,
        9,
        10,
        11
      ],
      "name": "Robert A. Bonomo",
      "orcid": "0000-0002-3299-894X"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Gabriel Gutkind",
      "orcid": "0000-0003-1999-9785"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "José Di Conza"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Diego M. Moreno",
      "orcid": "0000-0001-5493-8537"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Pablo Power",
      "orcid": "0000-0002-7051-9954"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0mt1qez08wam5.bib",
  "cited_by": 0,
  "doi": "10.1128/aac.00378-26",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13712949/",
  "id": "0mt1qez08wam5",
  "issns": [
    "0066-4804",
    "1098-6596"
  ],
  "landing_url": "https://doi.org/10.1128/aac.00378-26",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Mechanisms of Resistance"
    ],
    [
      "openalex",
      "1313|Antibiotic Resistance in Bacteria"
    ]
  ],
  "openalex": "W7169871459",
  "pdf_url": null,
  "pmcid": "PMC13712949",
  "pmid": "42479024",
  "published": "2026-07-21",
  "publisher": "American Society for Microbiology (ASM)",
  "ris": "https://research.draconitic.com/paper/0mt1qez08wam5.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:23:26Z",
      "native_id": "PMC13712949",
      "source": "pmc",
      "url": "https://doi.org/10.1128/aac.00378-26"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1313|Antibiotic Resistance in Bacteria",
      "subfield": "general"
    }
  ],
  "title": "PER-14, a β-lactamase variant with reduced sensitivity to avibactam and relebactam",
  "title_text": "PER-14, a β-lactamase variant with reduced sensitivity to avibactam and relebactam",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:23:26Z",
  "url": "https://research.draconitic.com/paper/0mt1qez08wam5",
  "venue": "Antimicrobial Agents and Chemotherapy",
  "versions": []
}