{
  "abstract": "The cellular mechanisms of omega-3 polyunsaturated fatty acid (ω3 PUFA) supplementation were investigated in inflammatory arthritis. Mice fed a prophylactic ω3 PUFA-enriched diet displayed reduced arthritis and paw oedema, with a discrete regulation of innate and stromal cell phenotypes in arthritic joints. Non-classical monocytes and VCAM-1 ⁺ synovial fibroblasts were lower at peak arthritis while pro-resolution MerTK ⁺ CD206 ⁺ macrophages were increased at resolution onset. Lipid mediator profiling of arthritic paws identified a distinct repertoire of molecules in ω3-fed mice, with elevated EPA-derived resolvin E2 (RvE2) and RvE4, compared with increased TXB ₂ and PGF 2α with a normal diet. Pharmacological treatment of mice with RvE2 and RvE4 concomitant with arthritis induction, attenuated arthritis and increased MerTK ⁺ CD206 ⁺ macrophages in arthritic joints. Synovial explant treatment revealed reduced pro-inflammatory mediator and enzyme release including IL-6, CCL2 and MMP-9. In arthritic patient blood, RvE2 and RvE4 (100 nM) lowered monocyte ICAM-1 expression. Collectively, these data identify cellular and molecular determinants of an ω3 diet in pre-clinical and human settings, highlighting therapeutic potential.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "name": "Chiara Cecconello",
      "orcid": "0009-0002-8469-4072"
    },
    {
      "name": "Pol Claria-Ribas"
    },
    {
      "name": "Celia Cartagena García"
    },
    {
      "name": "Jean-Marc Busnel"
    },
    {
      "name": "Jesmond Dalli"
    },
    {
      "name": "Mauro Perretti",
      "orcid": "0000-0003-2068-3331"
    },
    {
      "name": "Lucy V. Norling",
      "orcid": "0000-0001-5316-9115"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0n58bd8thdxwd.bib",
  "cited_by": 0,
  "doi": "10.1038/s42003-026-11193-w",
  "fulltext_url": null,
  "id": "0n58bd8thdxwd",
  "issns": [
    "2399-3642"
  ],
  "landing_url": "https://www.nature.com/articles/s42003-026-11193-w",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-29",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/0n58bd8thdxwd.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:50Z",
      "native_id": "10.1038/s42003-026-11193-w",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s42003-026-11193-w"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "issn:2399-3642",
      "subfield": "general"
    }
  ],
  "title": "Omega-3 PUFA supplementation promotes arthritis resolution by modulating joint cell phenotype involving E-series resolvins",
  "title_text": "Omega-3 PUFA supplementation promotes arthritis resolution by modulating joint cell phenotype involving E-series resolvins",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T00:20:36Z",
  "url": "https://research.draconitic.com/paper/0n58bd8thdxwd",
  "venue": "Communications Biology",
  "versions": []
}