{
  "abstract": "Mechanisms underlying symptomatic uncomplicated diverticular disease (SUDD) remain unclear. Here, we explored alterations in the gut microbiota associated with SUDD. Patients visiting outpatient clinics for refractory abdominal pain at five Japanese centers between February 2021 and May 2022 were prospectively enrolled. Patients diagnosed with SUDD (n = 29) and those with diverticulosis but not meeting the SUDD criteria (non-SUDD; n = 35) were included. Asymptomatic individuals served as healthy controls (HC; n = 68). Fecal samples were analyzed using 16 S rRNA gene sequencing. α-diversity indices were significantly lower in the SUDD and non-SUDD groups than in the HC group. β-diversity also differed significantly among groups. The abundance of the Ruminococcus gnavus group was higher in the SUDD group than in the non-SUDD and HC groups, whereas that of Coprococcus was lower. Butyrate-producing bacteria were less abundant in the SUDD group. Prediction-based (PICRUSt2) metagenomic analysis suggested upregulation of pathways, such as exopolysaccharide biosynthesis and cell cycle, in the SUDD group. Patients with SUDD exhibited dysbiosis, which may contribute to pathogenesis via impaired epithelial homeostasis, such as decreased mucosal butyrate concentration. The findings of this exploratory, observational study represent associations that require confirmation via direct functional and metabolomic measurements.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Gastroenterology, International University of Health and Welfare Ichikawa Hospital",
    "Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine",
    "Department of Gastroenterology, Graduate School of Medicine, International University of Health and Welfare",
    "Biofermin Pharmaceutical Co., Ltd.",
    "Department of Gastroenterology, International University of Health and Welfare Atami Hospital",
    "Department of Gastroenterology, Yokohama Sakae Kyosai Hospital",
    "Department of Internal Medicine, Kanagawa Dental University, Yokohama Clinic",
    "Department of Internal Medicine, Namiki Koiso-Medical Clinic",
    "Department of Biostatistics, JORTC Data Center",
    "Department of Pharmacology, Shimane University Faculty of Medicine",
    "Division of Gastroenterology, Nippon Medical School",
    "Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital",
    "Yong Loo Lin School of Medicine, National University of Singapore",
    "Territorial Gastroenterology Service, Azienda Sanitaria Locale Barletta-Andria-Trani"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 22,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Fumiaki Ishibashi"
    },
    {
      "affs": [
        1
      ],
      "name": "Tsumugi Jono"
    },
    {
      "affs": [
        1
      ],
      "name": "Yuki Kasai"
    },
    {
      "affs": [
        2
      ],
      "name": "Takaomi Kessoku"
    },
    {
      "affs": [
        3
      ],
      "name": "Haruka Yokota"
    },
    {
      "affs": [
        3
      ],
      "name": "Yoshiki Tanaka"
    },
    {
      "affs": [
        2
      ],
      "name": "Yo Ishihara"
    },
    {
      "affs": [
        1
      ],
      "name": "Kosuke Tanaka"
    },
    {
      "affs": [
        2
      ],
      "name": "Kota Takahashi"
    },
    {
      "affs": [
        4
      ],
      "name": "Kosuke Seita"
    },
    {
      "affs": [
        4
      ],
      "name": "Takayuki Kato"
    },
    {
      "affs": [
        5
      ],
      "name": "Eiji Sakai"
    },
    {
      "affs": [
        6
      ],
      "name": "Takeo Kurihashi"
    },
    {
      "affs": [
        7
      ],
      "name": "Machiko Nakatogawa"
    },
    {
      "affs": [
        8
      ],
      "name": "Shunsuke Oyamada"
    },
    {
      "affs": [
        9
      ],
      "name": "Haruki Usuda"
    },
    {
      "affs": [
        9
      ],
      "name": "Koichiro Wada"
    },
    {
      "affs": [
        10
      ],
      "name": "Seiji Futagami"
    },
    {
      "affs": [
        11
      ],
      "name": "Jonathan Wei Jie Lee"
    },
    {
      "affs": [
        12
      ],
      "name": "Kok-Ann Gwee"
    },
    {
      "affs": [
        13
      ],
      "name": "Antonio Tursi"
    },
    {
      "affs": [
        4
      ],
      "name": "Atsushi Nakajima"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0na27kca6gsq4.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-67357-5",
  "fulltext_url": "https://doi.org/10.1038/s41598-026-67357-5",
  "id": "0na27kca6gsq4",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://doi.org/10.1038/s41598-026-67357-5",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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  "pdf_url": "https://www.nature.com/articles/s41598-026-67357-5_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-01",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/0na27kca6gsq4.ris",
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    {
      "first_seen": "2026-11-01T14:21:19Z",
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  "subjects": [
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      "field": "biochemistry",
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      "subfield": "molecular-biology"
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  "title": "Significant alteration of gut microbiota in patients with symptomatic uncomplicated diverticular disease",
  "title_text": "Significant alteration of gut microbiota in patients with symptomatic uncomplicated diverticular disease",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T14:20:45Z",
  "url": "https://research.draconitic.com/paper/0na27kca6gsq4",
  "venue": "Scientific Reports",
  "versions": []
}