{
  "abstract": "KRAS (Kirsten-Ras) mutations are the most commonly occurring oncogenic drivers in non-small cell lung cancer. Despite the discovery of KRAS inhibitors representing a translational breakthrough for KRAS-driven cancers, resistance remains a major clinical challenge. We believe that to circumvent resistance, an in-depth understanding of the biological differences and therapeutic vulnerabilities specific to KRAS mutations is critical to inform rational combination partners with either mutant-selective or broad-spectrum (K)RAS inhibitors. The present review draws upon insights from both preclinical and clinical studies exploring KRAS-mutant allele-specific behaviours and therapeutic vulnerabilities. We will also highlight studies in which targeting of these vulnerabilities was combined with (K)RAS inhibitors, offering contextual examples of KRAS-mutant allele-tailored therapeutic strategies.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Wilmslow Road, The University of Manchester, Manchester, U.K.",
    "The Christie NHS Foundation Trust, Manchester, U.K.",
    "Cancer Research UK Lung Centre of Excellence, Manchester, U.K."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Paolo D. d'Arienzo",
      "orcid": "0000-0003-4792-2953"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "William J. McDaid",
      "orcid": "0009-0007-3442-4820"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Kirsten L. Tinsley"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Tong Chen"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Emma J. Gasson"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Colin R. Lindsay"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Angeliki Malliri",
      "orcid": "0000-0001-6848-090X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0nb5zb91gnks5.bib",
  "cited_by": 0,
  "doi": "10.1042/bcj20250138",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13714325/",
  "id": "0nb5zb91gnks5",
  "issns": [
    "0264-6021",
    "1470-8728"
  ],
  "landing_url": "https://doi.org/10.1042/bcj20250138",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Cancer"
    ],
    [
      "heading",
      "Mutation"
    ],
    [
      "heading",
      "Pharmacology & Toxicology"
    ],
    [
      "heading",
      "Review Articles"
    ],
    [
      "heading",
      "Signaling"
    ],
    [
      "heading",
      "Therapeutics & Molecular Medicine"
    ],
    [
      "openalex",
      "2740|Lung Cancer Treatments and Mutations"
    ]
  ],
  "openalex": "W7223948355",
  "pdf_url": "https://portlandpress.com/biochemj/article-pdf/483/11/2273/993311/bcj-2025-0138c.pdf",
  "pmcid": "PMC13714325",
  "pmid": "42936912",
  "published": "2026-10-27",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/0nb5zb91gnks5.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:21:50Z",
      "native_id": "PMC13714325",
      "source": "pmc",
      "url": "https://doi.org/10.1042/bcj20250138"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "heading:Cancer",
      "subfield": "oncology"
    }
  ],
  "title": "Uncovering KRAS-mutant allele-specific biology and vulnerabilities in non-small cell lung cancer",
  "title_text": "Uncovering KRAS-mutant allele-specific biology and vulnerabilities in non-small cell lung cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:21:50Z",
  "url": "https://research.draconitic.com/paper/0nb5zb91gnks5",
  "venue": "Biochemical Journal",
  "versions": []
}