{
  "abstract": "Background: Pancreatic cancer remains one of the most lethal malignancies, with limited curative options and poor long-term outcomes. Nuclear receptors, including PPAR{delta}, have been implicated in tumour progression. Methods: Retrospectively, we analysed 25 resected pancreatic cancer specimens from patients undergoing Whipple!s procedure (pancreatoduodenectomy) between 2000 and 2009. Immunohistochemistry was performed for PPAR{delta}. Tumour and stromal staining were assessed and correlated with clinicopathological features and survival data. Results: PPAR{delta} expression was observed in the majority of samples. This preliminary analysis suggests that PPAR{delta} expression is associated with adverse clinicopathological features and poorer survival. Conclusions: PPAR{delta} immunohistochemistry may identify a subset of pancreatic cancers with more aggressive biology. Larger studies are warranted to validate these findings.",
  "abstract_shown": true,
  "affiliations": [
    "University of Dundee"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "D. J. A. Adamson"
    },
    {
      "name": "S. V. Walsh"
    },
    {
      "name": "I. S. Tait"
    },
    {
      "affs": [
        0
      ],
      "name": "C. N. Palmer"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/0ncpsknbf0sd2.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.08.750098",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.08.750098v1.full",
  "id": "0ncpsknbf0sd2",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.08.750098v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "cancer biology"
    ],
    [
      "openalex",
      "2730|Pancreatic and Hepatic Oncology Research"
    ]
  ],
  "openalex": "W7212113355",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.08.750098v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-08",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/0ncpsknbf0sd2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:52Z",
      "native_id": "10.64898/2026.09.08.750098",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.08.750098v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "biorxiv:cancer biology",
      "subfield": "oncology"
    }
  ],
  "title": "PPARδ Expression and Prognosis in Resected Pancreatic Cancer: A Retrospective Single-Centre Study",
  "title_text": "PPARδ Expression and Prognosis in Resected Pancreatic Cancer: A Retrospective Single-Centre Study",
  "type": "preprint",
  "updated_at": "2026-10-30T12:20:52Z",
  "url": "https://research.draconitic.com/paper/0ncpsknbf0sd2",
  "venue": "bioRxiv",
  "versions": []
}